EIF3G and AIFM1

Number of citations of the paper that reports this interaction (PubMedID 17094969)
10

Data Source:
HPRD (two hybrid, in vitro)

		EIF3G	AIFM1
Description		eukaryotic translation initiation factor 3 subunit G	apoptosis inducing factor mitochondria associated 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	DNA Binding NADH Dehydrogenase Activity Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity, Acting On NAD(P)H Protein Dimerization Activity FAD Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Viral Translational Termination-reinitiation	Response To Ischemia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Toxic Substance Programmed Cell Death Chromosome Condensation Mitochondrial Respiratory Chain Complex Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Protein Import Into Mitochondrial Intermembrane Space Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Estradiol Stimulus Cellular Response To Nitric Oxide Cellular Response To Oxygen-glucose Deprivation Response To L-glutamate Regulation Of Apoptotic DNA Fragmentation Cellular Response To Aldosterone
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			Flavin adenine dinucleotide MCC
Diseases
GWAS			Bipolar disorder ( 31043756)
Interacting Genes		29 interacting genes: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 LMNA MEOX2 METTL3 MIF4GD MPHOSPH6 OGT PALS2 PIN1 PKN2 POT1 PRKAG1 SMN1 SNCA TK1 TRIM14	12 interacting genes: CASP3 DCAF7 EIF3G HSPA1A HSPA1B MLH1 NOA1 SETDB1 STC2 TSC22D4 WWC1 XIAP
Entrez ID		8666	9131
HPRD ID		04886	02161
Ensembl ID		ENSG00000130811	ENSG00000156709
Uniprot IDs		O75821	E9PMA0 O95831
PDB IDs		2CQ0 2MJC 5K0Y 6YBS 6ZMW	1M6I 4BUR 4BV6 4FDC 4LII 5FMH 5FS6 5FS7 5FS8 5FS9 5KVH 5KVI
Enriched GO Terms of Interacting Partners?
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