STC2 and ARHGEF40

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		STC2	ARHGEF40
Description		stanniocalcin 2	Rho guanine nucleotide exchange factor 40
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane
	Molecular Function	Hormone Activity Enzyme Binding Heme Binding Protein Homodimerization Activity	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Cellular Calcium Ion Homeostasis Signal Transduction Embryo Implantation Negative Regulation Of Gene Expression Response To Vitamin D Response To Peptide Hormone Decidualization Regulation Of Hormone Biosynthetic Process Cellular Response To Hypoxia	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015) Birth weight ( 31043758) Body shape index ( 34021172) Height ( 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Immunoglobulin A vasculitis ( 28698626) Prostate cancer ( 23535732) Retinitis pigmentosa ( 33514863) Urate levels in overweight individuals ( 25811787) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Neuroblastoma (pediatric) ( 32599975) Pediatric nonalcoholic steatohepatitis ( 28918882) Plateletcrit ( 32888494) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624)
Interacting Genes		20 interacting genes: ADAM11 AIFM1 ARHGEF40 ARRB2 CARHSP1 CELF6 CPN1 EIF2B3 ELOB ERGIC1 FAF2 FGFR4 HK3 PEBP1 PLA2G5 POLR2C POLR3F PPP1R8 PTN RNF44	7 interacting genes: APP CBY2 GPSM2 MAPT MYCBP STC2 TAC1
Entrez ID		8614	55701
HPRD ID		04717	13335
Ensembl ID		ENSG00000113739	ENSG00000165801
Uniprot IDs		O76061 Q6FHC9	Q8TER5
PDB IDs
Enriched GO Terms of Interacting Partners?
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