SSH2 and CFL1

Number of citations of the paper that reports this interaction (PubMedID 11832213)
230

Data Source:
HPRD (in vivo)

		SSH2	CFL1
Description		slingshot protein phosphatase 2	cofilin 1
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytoskeleton	Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix Lamellipodium Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Exosome
	Molecular Function	Actin Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding Actin Filament Binding
	Biological Process	Protein Dephosphorylation Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Peptidyl-tyrosine Dephosphorylation	Cytoskeleton Organization Rho Protein Signal Transduction Response To Virus Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Embryonic Development Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Process Cell Motility Actin Filament Severing Establishment Of Spindle Localization Regulation Of Dendritic Spine Morphogenesis
Pathways			Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Dodecyldimethylamine N-oxide Copper Artenimol
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Coffee consumption (cups per day) ( 25288136) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1/FVC) ( 30804560) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Peak expiratory flow ( 30804560) Red blood cell count ( 32888494) White blood cell count ( 32888494 27863252)	Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Neutrophil count ( 32888494) Platelet count ( 32888494) Psoriasis ( 28537254) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: ACTB BIRC5 CFL1	46 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CD5 CFL2 CLCN5 EGFR ERBB2 ERBB3 ERBB4 ESR1 HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP MYCBP2 NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UBE2M UCHL5 WDR1 YWHAG YWHAQ YWHAZ
Entrez ID		85464	1072
HPRD ID		09487	03261
Ensembl ID		ENSG00000141298	ENSG00000172757
Uniprot IDs		A0A3B3ITS1 B4DK64 F5H527 Q76I76	P23528 V9HWI5
PDB IDs		2NT2	1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W 6UBY 6UC0 6UC4 6VAO
Enriched GO Terms of Interacting Partners?
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