APOL1 and CACNA1I

		APOL1	CACNA1I
Description		apolipoprotein L1	calcium voltage-gated channel subunit alpha1 I
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Intrinsic Component Of Membrane Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Blood Microparticle	Voltage-gated Sodium Channel Complex Voltage-gated Calcium Channel Complex Neuron Projection
	Molecular Function	Chloride Channel Activity Protein Binding Lipid Binding	Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Low Voltage-gated Calcium Channel Activity
	Biological Process	Lipid Transport Cholesterol Metabolic Process Lipoprotein Metabolic Process Innate Immune Response Cytolysis By Host Of Symbiont Cells Chloride Transmembrane Transport	Signal Transduction Neuronal Action Potential Flagellated Sperm Motility Sleep Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	NCAM1 interactions
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Ergocalciferol Enflurane Amlodipine Spironolactone Cinnarizine Paramethadione Zonisamide Nifedipine Amiodarone Mibefradil Flunarizine Nylidrin Cannabidiol Trimebutine Benidipine Efonidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Diabetic kidney disease ( 26305897) End-stage kidney disease ( 31178898) End-stage renal disease ( 29885931) Glomerulosclerosis ( 20668430)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hodgkin's lymphoma ( 34216518) Household income (MTAG) ( 31844048) IgG glycosylation ( 23382691) Intelligence (MTAG) ( 29326435) Negative urgency ( 30718321) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Schizophrenia ( 28991256 22883433 29483656 30285260)
Interacting Genes		4 interacting genes: APOA1 CACNA1I CDC23 TRIM32	11 interacting genes: APOBEC1 APOL1 DNAL4 GTPBP1 HMGXB4 JOSD1 PICK1 PLA2G6 SYNGR1 TST VPS28
Entrez ID		8542	8911
HPRD ID		04774	10500
Ensembl ID		ENSG00000100342	ENSG00000100346
Uniprot IDs		B1AH95 O14791 Q2KHQ6	Q9P0X4
PDB IDs
Enriched GO Terms of Interacting Partners?
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