COPS3 and IL1RN

Number of citations of the paper that reports this interaction (PubMedID 15749898)
15

Data Source:
BioGRID (biochemical, far western blotting)

		COPS3	IL1RN
Description		COP9 signalosome subunit 3	interleukin 1 receptor antagonist
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome	Extracellular Space Cytoplasm Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Cytokine Activity Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity
	Biological Process	Protein Deneddylation In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus	Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Inflammatory Response Immune Response Signal Transduction Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Interleukin-10 signaling Interleukin-1 signaling
Drugs			Rilonacept
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576 29875488) C-reactive protein ( 22939635) C-reactive protein levels ( 33339817) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Interleukin-6 levels ( 33517400) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		32 interacting genes: ARAF ARF4 C17orf75 CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 COPS9 CSNK2A1 CSNK2B CUL5 FLAD1 FRS3 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 KRT80 LRP2BP MCPH1 MLF1 NABP1 PRXL2B RAF1 SOS1 TP53	6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP
Entrez ID		8533	3557
HPRD ID		07262	00978
Ensembl ID		ENSG00000141030	ENSG00000136689
Uniprot IDs		B4DN01 Q9UNS2	A0A024R528 P18510
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	1ILR 1ILT 1IRA 1IRP 1ITN 2IRT
Enriched GO Terms of Interacting Partners?
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