MMP23B and MTHFR

		MMP23B	MTHFR
Description		matrix metallopeptidase 23B	methylenetetrahydrofolate reductase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Membrane Integral Component Of Membrane Extracellular Matrix Collagen-containing Extracellular Matrix	Cytosol Synapse
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity Zinc Ion Binding	Methylenetetrahydrofolate Reductase (NAD(P)H) Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding NADP Binding FAD Binding Modified Amino Acid Binding Methylenetetrahydrofolate Reductase NADH Activity Methylenetetrahydrofolate Reductase NADPH Activity
	Biological Process	Reproduction Proteolysis Extracellular Matrix Organization Collagen Catabolic Process	Response To Hypoxia Neural Tube Closure Methionine Metabolic Process Methionine Biosynthetic Process Response To Xenobiotic Stimulus Regulation Of Histone Methylation Response To Vitamin B2 Tetrahydrofolate Interconversion Response To Amino Acid S-adenosylmethionine Metabolic Process Homocysteine Metabolic Process Response To Folic Acid Response To Interleukin-1
Pathways			Metabolism of folate and pterines
Drugs		Marimastat	Cyanocobalamin Tetrahydrofolic acid
Diseases
GWAS		Body mass index ( 26426971)	Atrial fibrillation ( 19597492) Blood pressure ( 21909110) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 28739976 27618452 29615537) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Early-onset schizophrenia ( 33907183) Folate pathway vitamin levels ( 19744961) High altitude adaptation ( 28373541) Hip index ( 34021172) Homocysteine levels ( 23824729 20031578 23696881) Hypertension ( 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (calcium channel blockers) ( 31015401) Midregional pro atrial natriuretic peptide levels ( 29237677) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Plasma homocysteine levels ( 30339177) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Red blood cell folate levels ( 30339177) Serum folate levels ( 30339177 29953918) Systolic blood pressure ( 19430483 27841878 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		3 interacting genes: GLRX MTHFR SRPK2	8 interacting genes: DDX21 FHL2 LSM8 MMP23B PRKCZ TP73 ZBTB17 ZNF239
Entrez ID		8510	4524
HPRD ID		04503	06158
Ensembl ID		ENSG00000189409	ENSG00000177000
Uniprot IDs		O75900	P42898 Q59GJ6 Q5SNW7 Q8IU67
PDB IDs			6FCX
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?