MTHFR and ZNF239

		MTHFR	ZNF239
Description		methylenetetrahydrofolate reductase	zinc finger protein 239
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Synapse	Nucleus
	Molecular Function	Methylenetetrahydrofolate Reductase (NAD(P)H) Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding NADP Binding FAD Binding Modified Amino Acid Binding Methylenetetrahydrofolate Reductase NADH Activity Methylenetetrahydrofolate Reductase NADPH Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding RNA Binding Protein Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Neural Tube Closure Methionine Metabolic Process Methionine Biosynthetic Process Response To Xenobiotic Stimulus Regulation Of Histone Methylation Response To Vitamin B2 Tetrahydrofolate Interconversion Response To Amino Acid S-adenosylmethionine Metabolic Process Homocysteine Metabolic Process Response To Folic Acid Response To Interleukin-1	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		Metabolism of folate and pterines
Drugs		Cyanocobalamin Tetrahydrofolic acid
Diseases
GWAS		Atrial fibrillation ( 19597492) Blood pressure ( 21909110) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 28739976 27618452 29615537) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Early-onset schizophrenia ( 33907183) Folate pathway vitamin levels ( 19744961) High altitude adaptation ( 28373541) Hip index ( 34021172) Homocysteine levels ( 23824729 20031578 23696881) Hypertension ( 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (calcium channel blockers) ( 31015401) Midregional pro atrial natriuretic peptide levels ( 29237677) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Plasma homocysteine levels ( 30339177) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Red blood cell folate levels ( 30339177) Serum folate levels ( 30339177 29953918) Systolic blood pressure ( 19430483 27841878 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		8 interacting genes: DDX21 FHL2 LSM8 MMP23B PRKCZ TP73 ZBTB17 ZNF239	8 interacting genes: CARD10 CEP70 KRTAP10-6 LMNA MTHFR MTUS2 RERE WTAP
Entrez ID		4524	8187
HPRD ID		06158	03044
Ensembl ID		ENSG00000177000	ENSG00000196793
Uniprot IDs		P42898 Q59GJ6 Q5SNW7 Q8IU67	Q16600
PDB IDs		6FCX
Enriched GO Terms of Interacting Partners?
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