REPS1 and RALBP1

Number of citations of the paper that reports this interaction (PubMedID 9395447)
38

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		REPS1	RALBP1
Description		RALBP1 associated Eps domain containing 1	ralA binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit	Spindle Pole Nucleus Mitochondrion Cytosol Plasma Membrane Membrane
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding	GTPase Activator Activity Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity Transmembrane Transporter Activity Small GTPase Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Endocytosis Receptor-mediated Endocytosis Endosomal Transport	Positive Regulation Of Protein Phosphorylation Endocytosis Chemotaxis Small GTPase Mediated Signal Transduction Regulation Of Cdc42 Protein Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Transmembrane Transport Positive Regulation Of Mitochondrial Fission Doxorubicin Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Type 2 diabetes ( 32499647)	LDL cholesterol ( 30275531)
Interacting Genes		17 interacting genes: ANKRD1 ATF4 CRK FLNC GRB2 HSF1 ITSN2 MZT1 PIN1 RAB11FIP2 RALA RALB RALBP1 REPS2 TRAPPC2 TRAPPC2L WWC2	46 interacting genes: AMOTL2 AP2M1 C1orf216 CASP8 CBY1 CCDC13 CCDC136 CCDC88B CCHCR1 CCNB1 CEP57 CREBZF DLG4 FADD GAS8 GSE1 HOOK2 HSF1 IKBKG KANK2 LDOC1 MSANTD4 PCM1 PLCG2 PPP1R13B PRKACA PRKCA RAC1 RALA RALB REPS1 REPS2 RHOU SAPCD2 SMARCE1 SYCE1 SYNJ2BP TBRG1 TCP10L TFPT TNIP1 TP53BP2 TRAF2 TSFM ZBTB38 ZNF707
Entrez ID		85021	10928
HPRD ID		09687	09013
Ensembl ID		ENSG00000135597	ENSG00000017797
Uniprot IDs		B2R7D3 Q96D71	Q15311
PDB IDs			2KWH 2KWI 2MBG 6ZQT 6ZRN
Enriched GO Terms of Interacting Partners?
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