TNS4 and PPP3CA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TNS4	PPP3CA
Description		tensin 4	protein phosphatase 3 catalytic subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Focal Adhesion	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Calcineurin Complex Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Plasma Membrane Z Disc Slit Diaphragm Sarcolemma Dendritic Spine Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cyclosporin A Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein-containing Complex Binding Protein Dimerization Activity ATPase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Apoptotic Process Protein Localization	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Brain Development Aging Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Dephosphorylation Positive Regulation Of Cell Migration Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Negative Regulation Of Chromatin Binding Wound Healing T Cell Activation Skeletal Muscle Tissue Regeneration Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Response To Calcium Ion Excitatory Postsynaptic Potential Peptidyl-serine Dephosphorylation Cellular Response To Glucose Stimulus Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Connective Tissue Replacement
Pathways		MET interacts with TNS proteins	DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs			Myristic acid
Diseases
GWAS		Asthma ( 31959851) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)	Adult body size ( 32376654) Anorexia nervosa ( 24514567) Bitter non-alcoholic beverage consumption ( 31046077) Blood pressure ( 22763476) Chronotype ( 30696823) Corneal structure ( 21979947) Trunk fat mass ( 28552196) Vitiligo ( 27723757)
Interacting Genes		27 interacting genes: AR CARD9 CBL CYSRT1 EGFR ERBB3 ERBB4 FKBP10 GAB1 GSTCD HDAC2 HSF2BP KAZN KCTD4 MET NME4 NR3C1 P4HA2 PIH1D1 PIK3R1 PPP3CA RABEP1 RPAIN TRIM21 TRIM27 TXK ZRANB1	45 interacting genes: AATK ABI2 AKAP5 AMPH ARMT1 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FAM167A FGFR4 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 ITPKB KCNIP3 KLHL3 MARCHF7 MYOZ2 MYOZ3 OGT PKD2 PLAC8 PPP3R1 PPP3R2 PRKCZ PTK7 RCAN1 RCAN2 RYK SHANK2 SNCA SOD1 STUB1 SYNJ1 TNS4 TRIM72 UBE4B UNC119
Entrez ID		84951	5530
HPRD ID		12223	00234
Ensembl ID		ENSG00000131746	ENSG00000138814
Uniprot IDs		Q6PJP3 Q8IZW8	A0A0S2Z4B5 A0A0S2Z4C6 Q08209
PDB IDs			1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z 4Q5U 5C1V 5SVE 6NUC 6NUF 6NUU 6UUQ
Enriched GO Terms of Interacting Partners?
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