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PPP3CA and BAD
Number of citations of the paper that reports this interaction (PubMedID
10195903
)
257
Data Source:
HPRD
(in vitro)
PPP3CA
BAD
Description
protein phosphatase 3 catalytic subunit alpha
BCL2 associated agonist of cell death
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Calcineurin Complex
Cytoplasmic Side Of Plasma Membrane
Extrinsic Component Of Plasma Membrane
Z Disc
Slit Diaphragm
Sarcolemma
Dendritic Spine
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Molecular Function
Protein Serine/threonine Phosphatase Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Cyclosporin A Binding
Enzyme Binding
Calmodulin-dependent Protein Phosphatase Activity
Protein-containing Complex Binding
Protein Dimerization Activity
ATPase Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Protein Binding
Phospholipid Binding
Lipid Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Protein Kinase Binding
Protein Phosphatase Binding
Protein Phosphatase 2B Binding
Protein Kinase B Binding
14-3-3 Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Response To Amphetamine
Protein Dephosphorylation
Protein Import Into Nucleus
Calcium Ion Transport
Brain Development
Aging
Transition Between Fast And Slow Fiber
Cardiac Muscle Hypertrophy In Response To Stress
Dephosphorylation
Positive Regulation Of Cell Migration
Calcineurin-NFAT Signaling Cascade
Multicellular Organismal Response To Stress
Negative Regulation Of Chromatin Binding
Wound Healing
T Cell Activation
Skeletal Muscle Tissue Regeneration
Positive Regulation Of Cell Adhesion
Positive Regulation Of Endocytosis
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Secretion
Skeletal Muscle Fiber Development
Negative Regulation Of Dendrite Morphogenesis
Positive Regulation Of DNA-binding Transcription Factor Activity
Response To Calcium Ion
Excitatory Postsynaptic Potential
Peptidyl-serine Dephosphorylation
Cellular Response To Glucose Stimulus
Calcineurin-mediated Signaling
Postsynaptic Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Connective Tissue Replacement
Release Of Cytochrome C From Mitochondria
Glucose Catabolic Process
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Spermatogenesis
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Xenobiotic Stimulus
Response To Glucose
Positive Regulation Of Autophagy
Positive Regulation Of Mitochondrial Membrane Potential
Cytokine-mediated Signaling Pathway
Cerebral Cortex Development
Positive Regulation Of Insulin Secretion
Response To Estradiol
Response To Progesterone
Positive Regulation Of Glucokinase Activity
Response To Testosterone
Response To Oleic Acid
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Response To Hydrogen Peroxide
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Response To Amino Acid
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Type B Pancreatic Cell Proliferation
Response To Ethanol
Positive Regulation Of B Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Proteolysis
ADP Metabolic Process
ATP Metabolic Process
Regulation Of Mitochondrial Membrane Permeability
Pore Complex Assembly
Positive Regulation Of Epithelial Cell Proliferation
Response To Glucocorticoid
Response To Calcium Ion
Cellular Response To Chromate
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Lipid
Cellular Response To Hypoxia
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Neuron Death
Response To Benzene
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Positive Regulation Of Granulosa Cell Apoptotic Process
Positive Regulation Of Type B Pancreatic Cell Development
Pathways
DARPP-32 events
Calcineurin activates NFAT
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation
Activation of BAD and translocation to mitochondria
Activation of BAD and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK
AKT phosphorylates targets in the cytosol
Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Myristic acid
Navitoclax
Diseases
GWAS
Adult body size (
32376654
)
Anorexia nervosa (
24514567
)
Bitter non-alcoholic beverage consumption (
31046077
)
Blood pressure (
22763476
)
Chronotype (
30696823
)
Corneal structure (
21979947
)
Trunk fat mass (
28552196
)
Vitiligo (
27723757
)
Crohn's disease (
28067908
)
Heel bone mineral density (
30598549
)
Platelet count (
22423221
)
Sarcoidosis (
22837380
)
Vitiligo (
27723757
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
45 interacting genes:
AATK
ABI2
AKAP5
AMPH
ARMT1
ATP2B4
BAD
BCL2
C16orf74
CABIN1
CASP3
CRTC2
FAM167A
FGFR4
FKBP1A
FKBP8
GABRA1
GABRB2
GABRG2
GRB2
ITPKB
KCNIP3
KLHL3
MARCHF7
MYOZ2
MYOZ3
OGT
PKD2
PLAC8
PPP3R1
PPP3R2
PRKCZ
PTK7
RCAN1
RCAN2
RYK
SHANK2
SNCA
SOD1
STUB1
SYNJ1
TNS4
TRIM72
UBE4B
UNC119
46 interacting genes:
ACTN2
AKT1
ARAF
BBS1
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BRAF
CDKN1A
CREB3L3
EWSR1
HRK
KEAP1
KRT31
MAP2K5
MAPK8
MCL1
PAK1
PAK5
PIM1
PIM2
PIM3
PPP1CA
PPP3CA
PRDX2
PRKACA
PRKCI
RAF1
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA5
S100A10
SFN
SNCA
STEAP3
SUMO2
WASF1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
5530
572
HPRD ID
00234
04409
Ensembl ID
ENSG00000138814
ENSG00000002330
Uniprot IDs
A0A0S2Z4B5
A0A0S2Z4C6
Q08209
A0A024R562
Q92934
PDB IDs
1AUI
1M63
1MF8
2JOG
2JZI
2P6B
2R28
2W73
3LL8
4F0Z
4Q5U
5C1V
5SVE
6NUC
6NUF
6NUU
6UUQ
1G5J
Enriched GO Terms of Interacting Partners
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