FZD8 and CUL2

		FZD8	CUL2
Description		frizzled class receptor 8	cullin 2
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane	Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuron Differentiation Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway
Pathways		Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination Signaling by RNF43 mutants	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		7 interacting genes: CUL2 GOPC LRP5 LRP6 RAE1 RYK WNT1	35 interacting genes: ABI1 ARID1B CAND1 CCND1 CDC34 CHD3 COMMD1 COPS5 CREM DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 FZD8 GJD4 GPS1 HSD17B7P2 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 UBE2D3 VHL ZER1 ZNF25 ZYG11B
Entrez ID		8325	8453
HPRD ID		05852	06786
Ensembl ID		ENSG00000177283	ENSG00000108094
Uniprot IDs		Q9H461	A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617
PDB IDs		5UN5 5UN6 6NDZ	4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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