MAP3K21 and MAP3K10

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		MAP3K21	MAP3K10
Description		mitogen-activated protein kinase kinase kinase 21	mitogen-activated protein kinase kinase kinase 10
Image
GO Annotations	Cellular Component	Cellular_component Cytoplasm	Cytoplasm
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Protein Autophosphorylation	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways
Drugs			Fostamatinib
Diseases
GWAS			Birth weight ( 31043758) Resting heart rate ( 27798624)
Interacting Genes		4 interacting genes: CLK1 MAP3K10 MAP3K11 STUB1	32 interacting genes: ABL2 CD47 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP3K21 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE
Entrez ID		84451	4294
HPRD ID		10087	02533
Ensembl ID		ENSG00000143674	ENSG00000130758
Uniprot IDs		Q5TCX8	Q02779
PDB IDs		4UYA	2RF0
Enriched GO Terms of Interacting Partners?
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