MAP3K10 and KIF17

Number of citations of the paper that reports this interaction (PubMedID 9427749)
71

Data Source:
BioGRID (two hybrid)

		MAP3K10	KIF17
Description		mitogen-activated protein kinase kinase kinase 10	kinesin family member 17
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Microtubule Organizing Center Cytosol Kinesin Complex Microtubule Cilium Axoneme Photoreceptor Connecting Cilium Dendrite Cytoplasm Ciliary Basal Body Neuron Projection Periciliary Membrane Compartment
	Molecular Function	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Serine Kinase Activity	Microtubule Motor Activity ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity
	Biological Process	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation	Microtubule-based Movement Protein Transport Vesicle-mediated Transport Cell Projection Organization Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Pathways			Intraflagellar transport Assembly and cell surface presentation of NMDA receptors
Drugs		Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Resting heart rate ( 27798624)	Ceramide levels (C24:0) ( 32489964) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Type 1 diabetes (age at diagnosis) ( 33179336)
Interacting Genes		32 interacting genes: ABL2 CD47 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP3K21 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE	8 interacting genes: APBA1 FHL5 FXR1 GFI1B MAP3K10 MAP3K11 PHAF1 XPO1
Entrez ID		4294	57576
HPRD ID		02533	10388
Ensembl ID		ENSG00000130758	ENSG00000117245
Uniprot IDs		Q02779	A0A0A0MRS8 Q9P2E2
PDB IDs		2RF0
Enriched GO Terms of Interacting Partners?
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