RHBDD1 and NSDHL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RHBDD1	NSDHL
Description		rhomboid domain containing 1	NAD(P) dependent steroid dehydrogenase-like
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	C-3 Sterol Dehydrogenase (C-4 Sterol Decarboxylase) Activity 3-beta-hydroxy-delta5-steroid Dehydrogenase Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) Activity 3-beta-hydroxysteroid Dehydrogenase/C4-decarboxylase Activity 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) Activity 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) Activity
	Biological Process	Apoptotic Process Positive Regulation Of Protein Processing Membrane Protein Intracellular Domain Proteolysis Cellular Response To Unfolded Protein Cellular Response To UV ERAD Pathway Negative Regulation Of Apoptotic Process Post-translational Protein Modification Spermatid Differentiation Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Regulation Of Male Germ Cell Proliferation	Hair Follicle Development Cholesterol Biosynthetic Process Smoothened Signaling Pathway Cholesterol Metabolic Process Labyrinthine Layer Blood Vessel Development
Pathways			Cholesterol biosynthesis
Drugs			NADH
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Kawasaki disease ( 33692975) Pulmonary function ( 17903307)	Glycated hemoglobin levels ( 34059833)
Interacting Genes		19 interacting genes: CGRRF1 CMTM5 CREB3L1 CTSA DAPK1 FBXO25 GYPC LPCAT2 LRRK2 MFHAS1 NSDHL PLEKHB2 RNF5 SEC22B SLC66A2 TGFA TMEM42 TMEM86B TMIE	5 interacting genes: DCC GPR35 RHBDD1 TMEM31 TMX2
Entrez ID		84236	50814
HPRD ID		13206	02229
Ensembl ID		ENSG00000144468	ENSG00000147383
Uniprot IDs		Q8TEB9	A0A384NPZ7 Q15738
PDB IDs		5EPP	6JKG 6JKH
Enriched GO Terms of Interacting Partners?
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