WDR24 and SESN3

Number of citations of the paper that reports this interaction (PubMedID 25263562)
166

Data Source:
BioGRID (pull down)

		WDR24	SESN3
Description		WD repeat domain 24	sestrin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Intracellular Membrane-bounded Organelle GATOR2 Complex	Nucleus Cytoplasm TORC2 Complex
	Molecular Function	Protein Binding	Protein Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Leucine Binding
	Biological Process	Autophagy Regulation Of Autophagy Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation	Positive Regulation Of Macroautophagy Response To Insulin Cellular Response To Amino Acid Starvation TORC2 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Kinase B Signaling Cellular Response To Leucine Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Amino acids regulate mTORC1	TP53 Regulates Metabolic Genes
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Hip circumference adjusted for BMI ( 34021172) Smoking initiation (ever regular vs never regular) ( 30679032)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Diastolic blood pressure ( 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		5 interacting genes: APPBP2 FBXO7 SESN1 SESN3 SRPK2	4 interacting genes: MIOS NPRL3 WDR24 WDR59
Entrez ID		84219	143686
HPRD ID		15665	09682
Ensembl ID		ENSG00000127580	ENSG00000149212
Uniprot IDs		Q96S15	P58005
PDB IDs
Enriched GO Terms of Interacting Partners?
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