ATRIP and SCG2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ATRIP	SCG2
Description		ATR interacting protein	secretogranin II
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Neuronal Dense Core Vesicle
	Molecular Function	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Cytokine Activity Protein Binding Chemoattractant Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair	MAPK Cascade Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response Protein Secretion Intracellular Signal Transduction Endothelial Cell Migration Eosinophil Chemotaxis Positive Chemotaxis Induction Of Positive Chemotaxis Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Airway wall thickness ( 25517131) Depression in smokers ( 30219690) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Fasting plasma glucose ( 32902719) Night sleep phenotypes ( 27126917) Osteoporosis-related phenotypes ( 20200953) Recurrent major depressive disorder x sex interaction ( 34099189) Response to hepatitis C treatment ( 22095909) Sodium levels ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		22 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP FAAP100 FAM156A LNX1 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SPRY2 TASOR2 ZBTB14	4 interacting genes: ATRIP TUBB4B UBQLN1 UBQLN4
Entrez ID		84126	7857
HPRD ID			06762
Ensembl ID		ENSG00000164053	ENSG00000171951
Uniprot IDs		A0A024R2U4 A0A024R307 Q8WXE1	P13521
PDB IDs		4IGK 4NB3 5YZ0
Enriched GO Terms of Interacting Partners?
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