ATRIP and CDK16

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ATRIP	CDK16
Description		ATR interacting protein	cyclin dependent kinase 16
Image
GO Annotations	Cellular Component	Nucleoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Microtubule Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Exocytosis Spermatogenesis Growth Hormone Secretion Neuron Projection Development Regulation Of Cell Cycle Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs			(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		22 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP FAAP100 FAM156A LNX1 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SPRY2 TASOR2 ZBTB14	18 interacting genes: APP APPBP2 ATRIP BAG6 CCND3 CDK5 CDK5R1 PJA1 PRKACA S100A10 SEC23A SIRPA YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB14
Entrez ID		84126	5127
HPRD ID			02409
Ensembl ID		ENSG00000164053	ENSG00000102225
Uniprot IDs		A0A024R2U4 A0A024R307 Q8WXE1	A0A024R183 A0A140VK97 Q00536 Q9BRL4
PDB IDs		4IGK 4NB3 5YZ0	3MTL 5G6V
Enriched GO Terms of Interacting Partners?
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