OBSCN and MYH2

Number of citations of the paper that reports this interaction (PubMedID 15013951)
32

Data Source:
HPRD (in vivo)

		OBSCN	MYH2
Description		obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	myosin heavy chain 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Nuclear Body Myofibril Z Disc M Band Sarcolemma	Cytosol Muscle Myosin Complex Cell-cell Junction Myofibril Sarcomere Myosin Filament Protein-containing Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Structural Constituent Of Muscle Phosphatidylinositol-5-phosphate Binding Ankyrin Binding Titin Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Cell Adhesion Molecule Binding Phosphatidylinositol-4-phosphate Binding Protein Serine Kinase Activity	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Actin Filament Binding
	Biological Process	Protein Phosphorylation Protein Localization To M-band Sarcomere Organization Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Cell-cell Adhesion	Muscle Contraction Muscle Filament Sliding
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOQ GTPase cycle	Regulation of actin dynamics for phagocytic cup formation FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433) PR interval ( 30046033 32439900)
Interacting Genes		8 interacting genes: ANK1 ANK2 BRCA1 CALM1 DNAJB5 MTDH MYH2 TTN	7 interacting genes: AMPD1 DGKD DUX4L9 OBSCN PRKCE PTK2B S100A4
Entrez ID		84033	4620
HPRD ID		10551	01173
Ensembl ID		ENSG00000154358	ENSG00000125414
Uniprot IDs		A6NGQ3 Q5VST9	Q9UKX2
PDB IDs		1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2MWC 2N56 2YZ8 4C4K 4RSV 4UOW 5TZM 6MG9
Enriched GO Terms of Interacting Partners?
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