KREMEN1 and DKK1

Number of citations of the paper that reports this interaction (PubMedID 12050670)
323

Data Source:
HPRD (in vitro, in vivo)

		KREMEN1	DKK1
Description		kringle containing transmembrane protein 1	dickkopf WNT signaling pathway inhibitor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Neuronal Cell Body	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding Growth Factor Activity Co-receptor Binding Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Apoptotic Process Cell Communication Multicellular Organism Development Wnt Signaling Pathway Negative Regulation Of Ossification Negative Regulation Of Axon Regeneration Limb Development Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Receptor Internalization Learning Or Memory Positive Regulation Of Gene Expression Positive Regulation Of Cell Death Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Negative Regulation Of Protein Binding Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Wnt Signaling Pathway, Calcium Modulating Pathway Limb Development Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Modulation Of Age-related Behavioral Decline Synapse Pruning Positive Regulation Of Neuron Death Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Tau-protein Kinase Activity Regulation Of Dopaminergic Neuron Differentiation Negative Regulation Of Wnt-Frizzled-LRP5/6 Complex Assembly Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Signaling Receptor Activity Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants
Drugs
Diseases
GWAS		Birth weight ( 31043758 27680694) Blood protein levels ( 30072576 29875488) Heel bone mineral density ( 30598549 28869591) Immature fraction of reticulocytes ( 32888494) Intraocular pressure ( 29617998) Pancreatic cancer ( 25086665) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Blood protein levels ( 29875488) Bone properties (heel) ( 24430505) Chin dimples ( 27182965) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Fractures ( 30158200) Logical memory (delayed recall) in normal cognition ( 29274321) Metabolite levels ( 23823483) Monobrow ( 27182965) Periodontitis (Mean PAL) ( 24024966) QRS complex (12-leadsum) ( 27659466) QRS complex (Cornell) ( 27659466) QRS duration ( 27577874 21076409 27659466) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		1 interacting genes: DKK1	8 interacting genes: CKAP4 DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9
Entrez ID		83999	22943
HPRD ID		11182	05544
Ensembl ID		ENSG00000183762	ENSG00000107984
Uniprot IDs		Q96MU8	I1W660 O94907
PDB IDs		5FWS 5FWT 5FWU 5FWV 5FWW 7BZT 7BZU	3S2K 3S8V 3SOQ 5FWW 5GJE
Enriched GO Terms of Interacting Partners?
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