DKK1 and LRP6

Number of citations of the paper that reports this interaction (PubMedID 11357136)
357

Data Source:
HPRD (in vivo)

		DKK1	LRP6
Description		dickkopf WNT signaling pathway inhibitor 1	LDL receptor related protein 6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane	Extracellular Region Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Early Endosome Membrane Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome
	Molecular Function	Protein Binding Growth Factor Activity Co-receptor Binding Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding	Low-density Lipoprotein Particle Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding Kinase Inhibitor Activity Toxin Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Receptor Internalization Learning Or Memory Positive Regulation Of Gene Expression Positive Regulation Of Cell Death Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Negative Regulation Of Protein Binding Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Wnt Signaling Pathway, Calcium Modulating Pathway Limb Development Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Modulation Of Age-related Behavioral Decline Synapse Pruning Positive Regulation Of Neuron Death Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Tau-protein Kinase Activity Regulation Of Dopaminergic Neuron Differentiation Negative Regulation Of Wnt-Frizzled-LRP5/6 Complex Assembly Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Signaling Receptor Activity Negative Regulation Of Cardiac Muscle Cell Differentiation	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Negative Regulation Of Smooth Muscle Cell Apoptotic Process Response To Peptide Hormone Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Protein Localization To Plasma Membrane Receptor-mediated Endocytosis Involved In Cholesterol Transport Wnt Signaling Pathway Involved In Somitogenesis Cell-cell Adhesion Toxin Transport Midbrain Dopaminergic Neuron Differentiation Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Bone properties (heel) ( 24430505) Chin dimples ( 27182965) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Fractures ( 30158200) Logical memory (delayed recall) in normal cognition ( 29274321) Metabolite levels ( 23823483) Monobrow ( 27182965) Periodontitis (Mean PAL) ( 24024966) QRS complex (12-leadsum) ( 27659466) QRS complex (Cornell) ( 27659466) QRS duration ( 27577874 21076409 27659466) Triglyceride levels x loop diuretics use interaction ( 31806883)	Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Coronary artery calcification ( 23870195) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tandem gait ( 26219847)
Interacting Genes		8 interacting genes: CKAP4 DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9	18 interacting genes: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 CKLF DKK1 DKK2 FZD5 FZD8 GSK3A GSK3B LRRK2 MDK SERPINF1 TLNRD1 WNT1 WNT3A
Entrez ID		22943	4040
HPRD ID		05544	04617
Ensembl ID		ENSG00000107984	ENSG00000070018
Uniprot IDs		I1W660 O94907	O75581
PDB IDs		3S2K 3S8V 3SOQ 5FWW 5GJE	3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6 4NM5 4NM7 5AIR 5FWW 5GJE 6H15 6H16 6L6R
Enriched GO Terms of Interacting Partners?
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