PIP5K1B and BTK

Number of citations of the paper that reports this interaction (PubMedID 15046600)
6

Data Source:
HPRD (in vivo, in vitro)

		PIP5K1B	BTK
Description		phosphatidylinositol-4-phosphate 5-kinase type 1 beta	Bruton tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Uropod Cytosol Plasma Membrane Endomembrane System	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phospholipase Activator Activity Identical Protein Binding Phospholipase Binding Metal Ion Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Phosphorylation Phosphatidylinositol Phosphate Biosynthetic Process	Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Cytokine Production Adaptive Immune Response B Cell Affinity Maturation Histamine Secretion By Mast Cell Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Protein Phosphorylation I-kappaB Kinase/NF-kappaB Signaling Mesoderm Development Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Negative Regulation Of B Cell Proliferation Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Innate Immune Response Positive Regulation Of B Cell Differentiation Protein Autophosphorylation Cell Maturation Regulation Of Catalytic Activity B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway Cellular Response To Interleukin-7
Pathways		Synthesis of PIPs at the plasma membrane WNT mediated activation of DVL PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization G alpha (q) signalling events G alpha (12/13) signalling events MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate WASPs and WAVEs G beta:gamma signalling through BTK FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Dasatinib Inositol 1,3,4,5-Tetrakisphosphate XL418 Ibrutinib Acalabrutinib Fostamatinib Zanubrutinib Abivertinib
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body mass index (recreational physical activity interaction) ( 23192594) Chronic kidney disease ( 31152163 20383146) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		2 interacting genes: BTK PIP5KL1	78 interacting genes: ABL1 APP AR ARHGAP17 ARID3A ARRB1 AURKA BCL2L11 BECN1 BLNK BMX CAV1 CBL CD19 CMTM3 COASY DAPP1 ERBB3 EWSR1 FAS FASLG FYN GAB1 GNA12 GNAQ GNB1 GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MDM2 MEOX2 MET MRPS22 MYD88 PIK3AP1 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 SMURF1 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TNFRSF18 TP53 VAV1 WAS WASF2
Entrez ID		8395	695
HPRD ID		04121	02248
Ensembl ID		ENSG00000107242	ENSG00000010671
Uniprot IDs		O14986 Q7KYT6	Q06187 Q5JY90
PDB IDs			1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3 4NWM 4OT5 4OT6 4OTF 4OTQ 4OTR 4RFY 4RFZ 4RG0 4RX5 4YHF 4Z3V 4ZLY 4ZLZ 5BPY 5BQ0 5FBN 5FBO 5J87 5JRS 5KUP 5P9F 5P9G 5P9H 5P9I 5P9J 5P9K 5P9L 5P9M 5T18 5U9D 5VFI 5VGO 5XYZ 5ZZ4 6AUA 6AUB 6BIK 6BKE 6BKH 6BKW 6BLN 6DI0 6DI1 6DI3 6DI5 6DI9 6E4F 6EP9 6HRP 6HRT 6HTF 6J6M 6N9P 6NFH 6NFI 6NZM 6O8I 6OMU 6S90 6TFP 6TSE 6TT2 6TUH 6TVN 6VXQ 6W06 6W07 6W7O 6W8I 6X3N 6X3O 6X3P 6XE4
Enriched GO Terms of Interacting Partners?
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