TMTC1 and CCDC91

		TMTC1	CCDC91
Description		transmembrane O-mannosyltransferase targeting cadherins 1	coiled-coil domain containing 91
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Membrane	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane
	Molecular Function	Mannosyltransferase Activity Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity
	Biological Process	RNA Processing Protein O-linked Mannosylation	Protein Transport Golgi To Lysosome Transport
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170) Colorectal or endometrial cancer ( 26621817) Compulsion score in obsessive compulsive disorder ( 32063569) Heart failure ( 20445134) Hippocampal volume ( 29860282) Schizophrenia ( 28991256 22885689 25056061 29483656 30285260)	Adverse response to drug ( 30420678) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone ultrasound measurement (velocity of sound) ( 28472463) Brain morphology (MOSTest) ( 32665545) Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561 33909500) FEV1 ( 30804560) Finger osteoarthritis severity (hand Klsum) ( 33055079) Glaucoma (primary open-angle) ( 33627673) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hand osteoarthritis severity (hand Klsum) ( 33055079) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 23563607 31562340) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172 25673412) Immature fraction of reticulocytes ( 32888494) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function (FEV1) ( 28166213 26635082) Lung function (FVC) ( 28166213 26635082 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Narrowest width of the femoral neck ( 30888730) Obesity-related traits ( 23251661) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis of the hand ( 28855172) Peak expiratory flow ( 30804560) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)
Interacting Genes		3 interacting genes: CCDC91 OVCH1 ZDHHC17	12 interacting genes: AP1G1 CDC37 DAPK2 ECT2 EWSR1 GGA1 GGA2 LNX1 PRR5L SYNRG TESC TMTC1
Entrez ID		83857	55297
HPRD ID		12472	16905
Ensembl ID		ENSG00000133687	ENSG00000123106
Uniprot IDs		Q8IUR5	A0A024RAW6 Q05D28 Q7Z6B0
PDB IDs			1OM9
Enriched GO Terms of Interacting Partners?
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