CCDC91 and DAPK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CCDC91	DAPK2
Description		coiled-coil domain containing 91	death associated protein kinase 2
Image
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane	Nucleus Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Autophagosome Lumen Intracellular Membrane-bounded Organelle
	Molecular Function		Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Transport Golgi To Lysosome Transport	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Anoikis Protein Autophosphorylation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Eosinophil Chemotaxis Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Caspase activation via Dependence Receptors in the absence of ligand
Drugs			Fostamatinib
Diseases
GWAS		Adverse response to drug ( 30420678) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone ultrasound measurement (velocity of sound) ( 28472463) Brain morphology (MOSTest) ( 32665545) Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561 33909500) FEV1 ( 30804560) Finger osteoarthritis severity (hand Klsum) ( 33055079) Glaucoma (primary open-angle) ( 33627673) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hand osteoarthritis severity (hand Klsum) ( 33055079) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 23563607 31562340) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172 25673412) Immature fraction of reticulocytes ( 32888494) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function (FEV1) ( 28166213 26635082) Lung function (FVC) ( 28166213 26635082 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Narrowest width of the femoral neck ( 30888730) Obesity-related traits ( 23251661) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis of the hand ( 28855172) Peak expiratory flow ( 30804560) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)	Arterial stiffness index ( 31235810) Blood protein levels ( 28240269) Cerebral amyloid deposition (PET imaging) ( 30361487) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) HDL cholesterol levels ( 32203549) Platelet distribution width ( 27863252) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Triglyceride levels ( 31647587) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		12 interacting genes: AP1G1 CDC37 DAPK2 ECT2 EWSR1 GGA1 GGA2 LNX1 PRR5L SYNRG TESC TMTC1	8 interacting genes: APP ATP6V0B CAMK2A CCDC91 FAM9B MLC1 STK4 TGFBR1
Entrez ID		55297	23604
HPRD ID		16905	09905
Ensembl ID		ENSG00000123106	ENSG00000035664
Uniprot IDs		A0A024RAW6 Q05D28 Q7Z6B0	A0A024R603 Q9UIK4
PDB IDs		1OM9	1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE 6PAW
Enriched GO Terms of Interacting Partners?
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