H4C1 and PAK1

Number of citations of the paper that reports this interaction (PubMedID 15864311)
41

Data Source:
HPRD (in vitro)

		H4C1	PAK1
Description		H4 clustered histone 1	p21 (RAC1) activated kinase 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein-containing Complex Extracellular Exosome	Ruffle Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Cytosol Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Z Disc Lamellipodium Axon Dendrite Nuclear Membrane Ruffle Membrane Protein-containing Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding Protein Domain Specific Binding Protein Heterodimerization Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Kinase Binding Small GTPase Binding Gamma-tubulin Binding Protein Serine Kinase Activity
	Biological Process	Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly DNA-templated Transcription, Initiation Telomere Organization Negative Regulation Of Megakaryocyte Differentiation	MAPK Cascade Response To Hypoxia Positive Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Remodeling Protein Phosphorylation Exocytosis Apoptotic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Positive Regulation Of Fibroblast Migration Phosphorylation Cell Migration Cerebellum Development Establishment Of Cell Polarity Positive Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Actin Cytoskeleton Reorganization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Positive Regulation Of Axon Extension Positive Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation Hepatocyte Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Microtubule Nucleation Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Amyloid fiber formation	Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation DSCAM interactions CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS			Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)
Interacting Genes		76 interacting genes: ANP32A ANP32B ASF1A BAZ2A CBX3 CDK1 CDK2 CHD4 COPS2 CREBBP DPF2 DYRK1A EID1 ELP3 EP300 ERCC6 EXO1 FANCD2 GATAD2A GATAD2B H2AC20 HAT1 HDAC3 HDAC8 HIRIP3 HJURP JADE1 JMJD6 KAT14 KAT2B KAT5 KAT6A KAT7 KAT8 KDM4A KMT2C KMT2D KMT5B KMT5C L3MBTL2 MBTD1 MRE11 MSL2 MSL3 MYB NAP1L1 NCOR1 NCOR2 NSD1 NSD3 PAK1 PALB2 PARP10 PBRM1 PELP1 PHF1 PHF20 PHF8 PRMT5 PRMT7 PRMT8 PSME4 PTMA SETD7 SHPRH SIRT7 TAF1A TAF1B TBL1X THAP7 TLE3 TP53BP1 TRIM28 TRIM29 UCHL5 WBP2	85 interacting genes: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CPLANE1 CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 H3C1 H4C1 HACE1 HGS HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1A PPM1F PPP1CA PPP2CA PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83
Entrez ID		8359	5058
HPRD ID		04157	03995
Ensembl ID		ENSG00000278637	ENSG00000149269
Uniprot IDs		B2R4R0 P62805	A0A024R5P0 Q13153
PDB IDs		1ZKK 2BQZ 2CV5 2IG0 2KWN 2KWO 2LVM 2QQS 2RJE 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3IJ1 3JPX 3NQJ 3NQU 3O36 3QBY 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3WTP 3X1S 3X1T 3X1U 3X1V 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4M38 4N3W 4N4F 4QUT 4QUU 4QYD 4U9W 4YM5 4YM6 4YY6 4YYD 4YYG 4YYH 4YYI 4YYJ 4YYK 4YYM 4YYN 4Z2M 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B33 5B40 5BNV 5BNX 5BO0 5C3I 5CPI 5CPJ 5CPK 5FA5 5FFW 5FWE 5GSE 5GSU 5GT0 5GT3 5GTC 5GXQ 5JA4 5JRG 5KDM 5TEG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5YE3 5YE4 5Z23 5Z30 5ZBX 5ZGC 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACP 6BUZ 6C0W 6E0C 6E0P 6FML 6HKT 6HTS 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JOU 6JR0 6JR1 6K1I 6K1J 6K1K 6KE9 6KVD 6KXV 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6M3V 6M44 6M4D 6M4G 6M4H 6MLC 6MUO 6MUP 6O1D 6R0C 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6RNY 6RXS 6SE0 6SE6 6SEE 6SEF 6SEG 6T79 6T7A 6T7B 6T7C 6T7D 6T90 6T93 6UPK 6UPL 6USJ 6V2K 6V92 6VO5 6X59 6X5A 6XJD 6Y5D 6YOV 7A08 7BXT 7BY0 7C0M 7CCQ 7CCR 7D1Z 7D20 7DBP 7JO9 7JOA 7JZV 7K5X 7K5Y 7K60 7K61 7K63 7LMK 7LMM	1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY 5DFP 5IME 5KBQ 5KBR 6B16
Enriched GO Terms of Interacting Partners?
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