NCOA3 and RARG

Number of citations of the paper that reports this interaction (PubMedID 15604093)
56

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		NCOA3	RARG
Description		nuclear receptor coactivator 3	retinoic acid receptor gamma
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Complex Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Nuclear Receptor Coactivator Activity Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Disordered Domain Specific Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Retinoid X Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Histone Acetylation Cellular Response To Hormone Stimulus Receptor Transactivation Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Glandular Epithelial Cell Development Growth Plate Cartilage Chondrocyte Growth Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Size Hormone-mediated Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Cell Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Canonical Wnt Signaling Pathway Face Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Harderian Gland Development Cellular Response To Retinoic Acid Cellular Response To Leukemia Inhibitory Factor
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression	Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin SR11254 BMS-181156 CD564 Dodecyl-Alpha-D-Maltoside BMS184394 R667 LGD-1550 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid Trifarotene
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)	Anthracycline-induced cardiotoxicity in childhood cancer ( 26237429) Cardiorespiratory fitness (800m run time) ( 32572135) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
Interacting Genes		82 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4-16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SLC22A2 SMARCE1 SPOP SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ	35 interacting genes: ACY3 ARID1A BBS4 HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 MYF5 NCOA1 NCOA3 NCOR1 NCOR2 NEK9 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 PRIM1 PRKAR1B PSMC5 RHPN2 RXRA RXRB RXRG S100A3 SMAD3 SMARCD3 SPHK1 TNIP1 ZNF576
Entrez ID		8202	5916
HPRD ID		03570	01573
Ensembl ID		ENSG00000124151	ENSG00000172819
Uniprot IDs		Q59EE8 Q9Y6Q9	A8K3H3 B7Z4B4 F1D8P1 P13631
PDB IDs		1KBH 3L3X 3L3Z 6ES7 6SQC	1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD 5M24 6FX0
Enriched GO Terms of Interacting Partners?
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