SYMPK and MIR214

Number of citations of the paper that reports this interaction (PubMedID 28431233)
92

Data Source:
BioGRID (unspecified method)

		SYMPK	MIR214
Description		symplekin scaffold protein	microRNA 214
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cytoskeleton Plasma Membrane Bicellular Tight Junction Nuclear Body Nuclear Stress Granule	Nucleus Perinuclear Region Of Cytoplasm Extracellular Vesicle
	Molecular Function	Protein Binding	MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	MRNA Polyadenylation Cell Adhesion Negative Regulation Of Protein Binding Positive Regulation Of Protein Dephosphorylation	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Gene Expression Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Gene Silencing By MiRNA Negative Regulation Of Necroptotic Process Cellular Response To Hypoxia Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Connective Tissue Replacement
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Asthma ( 31959851) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Colon cancer ( 28295283) Colorectal cancer ( 28295283) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494)	Height ( 31562340)
Interacting Genes		45 interacting genes: CSTF2 HSF1 HTT MIR1-2 MIR107 MIR128-2 MIR138-2 MIR155 MIR15B MIR16-2 MIR17 MIR18A MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR20B MIR21 MIR214 MIR25 MIR29A MIR34A MIR363 MIR7-2 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7D MIRLET7E MIRLET7G MIRLET7I RIN3 SUMO2 TOP1 TRIM55 TRIM63 UBE2I YBX3	92 interacting genes: AIMP1 AIMP2 AQR ATXN2L C1QBP CDC5L CELF1 CPSF1 DARS1 DDX1 DDX21 DDX23 DDX3X DDX49 DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PTBP1 PTCD3 PUF60 PUM1 PUM2 QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM4 RBM4B RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZC3H11A ZFR ZNF346
Entrez ID		8189	406996
HPRD ID		09090
Ensembl ID		ENSG00000125755	ENSG00000283844
Uniprot IDs		A0A024R0R6 Q92797
PDB IDs		3O2Q 3O2S 3O2T 3ODR 3ODS 4H3H 4H3K 6V4X
Enriched GO Terms of Interacting Partners?
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