SPACA1 and ATP6V0B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPACA1	ATP6V0B
Description		sperm acrosome associated 1	ATPase H+ transporting V0 subunit b
Image		No pdb structure
GO Annotations	Cellular Component	Inner Acrosomal Membrane Acrosomal Membrane Integral Component Of Membrane	Lysosomal Membrane Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain
	Molecular Function	Protein Binding	Transporter Activity Protein Binding Proton Transmembrane Transporter Activity
	Biological Process	Acrosome Assembly	Regulation Of Macroautophagy Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS		Echocardiographic traits ( 17903301) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		25 interacting genes: AGPAT4 ATP6V0B ATP6V0C BNIP3 CACNG7 CD72 CLDN19 CTXN3 EMP1 EMP3 GIMAP5 LSMEM2 NRSN1 NSG1 PLN PMP22 RPRM SERP2 SERTM1 SGCG SMAGP SMIM3 THSD7B TMEM140 TMEM47	34 interacting genes: ADGRG3 ADRB2 APOD BPI CCL19 COL4A5 DAPK2 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM RPS26P15 SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 TTC39A VMA21 YWHAE YWHAG ZFYVE9
Entrez ID		81833	533
HPRD ID		15419	04759
Ensembl ID		ENSG00000118434	ENSG00000117410
Uniprot IDs		Q9HBV2	E9PNL3 Q99437
PDB IDs			6WLW 6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
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