ATP6V0B and BPI

		ATP6V0B	BPI
Description		ATPase H+ transporting V0 subunit b	bactericidal permeability increasing protein
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GO Annotations	Cellular Component	Lysosomal Membrane Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain	Extracellular Region Extracellular Space Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	Transporter Activity Protein Binding Proton Transmembrane Transporter Activity	Lipopolysaccharide Binding
	Biological Process	Regulation Of Macroautophagy Proton Transmembrane Transport	Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides
Drugs		Tiludronic acid	Di-Stearoyl-3-Sn-Phosphatidylcholine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Basophil count ( 32888494) Blood protein levels ( 29875488) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		34 interacting genes: ADGRG3 ADRB2 APOD BPI CCL19 COL4A5 DAPK2 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM RPS26P15 SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 TTC39A VMA21 YWHAE YWHAG ZFYVE9	2 interacting genes: ATP6V0B PRSS2
Entrez ID		533	671
HPRD ID		04759	00174
Ensembl ID		ENSG00000117410	ENSG00000101425
Uniprot IDs		E9PNL3 Q99437	P17213
PDB IDs		6WLW 6WM2 6WM3 6WM4	1BP1 1EWF
Enriched GO Terms of Interacting Partners?
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