CCNL2 and DYRK1A

Number of citations of the paper that reports this interaction (PubMedID 14623875)
38

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo, in vitro)

		CCNL2	DYRK1A
Description		cyclin L2	dual specificity tyrosine phosphorylation regulated kinase 1A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Nuclear Speck Axon Dendrite Ribonucleoprotein Complex
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity	Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Microtubule Polymerization Positive Regulation Of RNA Splicing Amyloid-beta Formation Peptidyl-serine Autophosphorylation Peptidyl-tyrosine Autophosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Deacetylation
Pathways			G0 and Early G1
Drugs			N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide Fostamatinib
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) HIV-1 replication ( 21364930) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Neutrophil count ( 32888494) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Stroke ( 30383316) Systolic blood pressure ( 32902719) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: CDK11B DYRK1A EMD FAM90A1 KRTAP12-2 MAGEB2 MDFI PIH1D2 POLR2A RUNDC3A SRSF2 SRSF7 TRIM41 USP20 ZBTB7B	34 interacting genes: - AMPH APP CCNL2 CLASRP CREB1 CREBBP EIF2B5 FOXO1 GLI1 H2BC3 H3C1 H4C1 ID2 KPRP LATS2 LIN52 MAPT PEA15 PHYHIP PRKN RAD51 RB1 RBL1 RNF169 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG
Entrez ID		81669	1859
HPRD ID		10815	09018
Ensembl ID		ENSG00000221978	ENSG00000157540
Uniprot IDs		Q96S94	A0A2R8Y6I6 Q13627
PDB IDs			2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK 6A1F 6A1G 6EIF 6EIJ 6EIL 6EIP 6EIQ 6EIR 6EIS 6EIV 6EJ4 6QU2 6S11 6S14 6S17 6S1B 6S1H 6S1I 6S1J 6T6A 6UIP 6UWY
Enriched GO Terms of Interacting Partners?
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