DYRK1A and RNF169

Number of citations of the paper that reports this interaction (PubMedID 26949739)
19

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		DYRK1A	RNF169
Description		dual specificity tyrosine phosphorylation regulated kinase 1A	ring finger protein 169
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Nuclear Speck Axon Dendrite Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body Site Of Double-strand Break
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Protein Binding Transferase Activity Nucleosome Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Microtubule Polymerization Positive Regulation Of RNA Splicing Amyloid-beta Formation Peptidyl-serine Autophosphorylation Peptidyl-tyrosine Autophosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Deacetylation	Cellular Response To DNA Damage Stimulus Protein Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways		G0 and Early G1
Drugs		N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide Fostamatinib
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) HIV-1 replication ( 21364930) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Neutrophil count ( 32888494) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Stroke ( 30383316) Systolic blood pressure ( 32902719) White blood cell count ( 32888494)
Interacting Genes		34 interacting genes: - AMPH APP CCNL2 CLASRP CREB1 CREBBP EIF2B5 FOXO1 GLI1 H2BC3 H3C1 H4C1 ID2 KPRP LATS2 LIN52 MAPT PEA15 PHYHIP PRKN RAD51 RB1 RBL1 RNF169 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG	11 interacting genes: CEP70 DYRK1A GOLGA2 H2AC18 H2AC4 H2AZ1 HOOK2 HSF2BP PIBF1 UBC UBE2E1
Entrez ID		1859	254225
HPRD ID		09018	19383
Ensembl ID		ENSG00000157540	ENSG00000166439
Uniprot IDs		A0A2R8Y6I6 Q13627	Q8NCN4
PDB IDs		2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK 6A1F 6A1G 6EIF 6EIJ 6EIL 6EIP 6EIQ 6EIR 6EIS 6EIV 6EJ4 6QU2 6S11 6S14 6S17 6S1B 6S1H 6S1I 6S1J 6T6A 6UIP 6UWY	5GG4 5VEY
Enriched GO Terms of Interacting Partners?
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