SIAH1 and MAPK12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		SIAH1	MAPK12
Description		siah E3 ubiquitin protein ligase 1	mitogen-activated protein kinase 12
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Beta-catenin Destruction Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Ubiquitination Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Amyloid Fibril Formation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	MAPK Cascade DNA Damage Induced Protein Phosphorylation Cell Cycle Signal Transduction Muscle Organ Development Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Intracellular Signal Transduction Myoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Muscle Cell Differentiation Regulation Of Cell Cycle
Pathways		Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation DSCAM interactions VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway
Drugs			Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Height ( 28552196) Mean corpuscular hemoglobin ( 32888494) Waist circumference ( 28552196)	Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		152 interacting genes: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4-16 HCFC1 HIF1AN HIPK2 HIPK3 INHA IQCN KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PKD1 POU2AF1 PRPF31 PRR20A PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RICTOR RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLC9A3R2 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX	29 interacting genes: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1
Entrez ID		6477	6300
HPRD ID		03736	03868
Ensembl ID		ENSG00000196470	ENSG00000188130
Uniprot IDs		Q8IUQ4	P53778 Q6N076
PDB IDs		2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ	1CM8 4QUM 6UNA
Enriched GO Terms of Interacting Partners?
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