PABPN1 and LATS1

Number of citations of the paper that reports this interaction (PubMedID 24107629)
33

Data Source:
BioGRID (unspecified method)

		PABPN1	LATS1
Description		poly(A) binding protein nuclear 1	large tumor suppressor kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Nuclear Inclusion Body Ribonucleoprotein Complex	Spindle Pole Nucleus Microtubule Organizing Center Cytosol Midbody
	Molecular Function	RNA Binding Protein Binding RNA Polymerase Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Estrogen Receptor Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade RNA Processing MRNA Processing Muscle Contraction Poly(A)+ MRNA Export From Nucleus Cellular Response To Lipopolysaccharide Positive Regulation Of Polynucleotide Adenylyltransferase Activity	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-serine Phosphorylation Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cytoplasmic Sequestering Of Protein Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Inhibition of Host mRNA Processing and RNA Silencing mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Signaling by Hippo
Drugs			Fostamatinib
Diseases
GWAS		Body mass index ( 26865924) Lymphocyte counts ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Brain morphology (MOSTest) ( 32665545) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)
Interacting Genes		16 interacting genes: AKAP6 CARM1 DNAJB4 HNRNPA1 HSP90AA1 IL7R LATS1 LINC00839 MYCBP2 OGT PRMT3 SMARCA4 SNW1 STAU1 TNPO1 YWHAQ	46 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LRRK2 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK3 STK4 SYNE1 TAFAZZIN TFIP11 TRAF1 UBE2I WWOX WWP1 WWTR1 ZYX
Entrez ID		8106	9113
HPRD ID		03787	09147
Ensembl ID		ENSG00000100836	ENSG00000131023
Uniprot IDs		Q86U42	O95835
PDB IDs		3B4D 3B4M 3UCG	4ZRK 5B5W 5BRK
Enriched GO Terms of Interacting Partners?
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