COL18A1 and GPC1

Number of citations of the paper that reports this interaction (PubMedID 11336704)
62

Data Source:
HPRD (in vitro, in vivo)

		COL18A1	GPC1
Description		collagen type XVIII alpha 1 chain	glypican 1
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Nucleoplasm Endosome Golgi Lumen Cytosol Plasma Membrane Cell Surface Extracellular Matrix Intrinsic Component Of Plasma Membrane Lysosomal Lumen Membrane Raft Synapse Anchored Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding	Copper Ion Binding Fibroblast Growth Factor Binding Laminin Binding
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Animal Organ Morphogenesis Extracellular Matrix Organization Response To Hydrostatic Pressure	Schwann Cell Differentiation Cell Migration Heparan Sulfate Proteoglycan Catabolic Process Myelin Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Laminin interactions Collagen chain trimerization	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Signaling by ROBO receptors Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs
Diseases
GWAS		Ankle injury ( 28957384) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576 29875488) Bone mineral density (total hip) ( 29883787) Brain morphology (MOSTest) ( 32665545) Cardiorespiratory fitness (800m run time) ( 32572135) Early-onset Parkinson's disease ( 28256260) HDL cholesterol levels ( 32203549) Hippocampal atrophy ( 22745009) Leftâ€“right brain asymmetry ( 33723403) Platelet distribution width ( 32888494) Pursuit maintenance gain ( 29064472) Total cholesterol levels ( 30275531) Triglycerides ( 24507774 30275531)	Blood protein levels ( 29875488) BMI x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125)
Interacting Genes		9 interacting genes: CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 KDR MMP2 PTEN	5 interacting genes: APP COL18A1 SLIT1 SLIT2 VEGFA
Entrez ID		80781	2817
HPRD ID		00382	02671
Ensembl ID		ENSG00000182871	ENSG00000063660
Uniprot IDs		D3DSM4 D3DSM5 P39060	A0A384NPH9 H7C410 P35052
PDB IDs		1BNL 3HON 3HSH	4ACR 4AD7 4BWE 4YWT
Enriched GO Terms of Interacting Partners?
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