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CEP70 and CDC37
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
CEP70
CDC37
Description
centrosomal protein 70
cell division cycle 37, HSP90 cochaperone
Image
No pdb structure
GO Annotations
Cellular Component
Centrosome
Cytosol
Cytoplasm
Cytosol
Extracellular Exosome
Chaperone Complex
HSP90-CDC37 Chaperone Complex
Molecular Function
Protein Binding
Identical Protein Binding
Gamma-tubulin Binding
Protein Binding
Protein Kinase Regulator Activity
Kinase Binding
Protein Kinase Binding
Heat Shock Protein Binding
Unfolded Protein Binding
Chaperone Binding
Hsp90 Protein Binding
Scaffold Protein Binding
Biological Process
Cilium Assembly
Regulation Of Microtubule Cytoskeleton Organization
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Folding
Protein Targeting
Posttranscriptional Regulation Of Gene Expression
Protein Stabilization
Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Constitutive Signaling by EGFRvIII
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
RHOBTB2 GTPase cycle
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS
Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease (
29631575
)
Male-pattern baldness (
28196072
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
LDL cholesterol levels in HIV infection (
33109212
)
Multiple sclerosis (
21833088
)
White blood cell count (
32888494
)
Interacting Genes
242 interacting genes:
ABT1
AGBL2
AKAP17A
ARHGEF3
ARMCX1
ATP5PO
ATXN7
BARD1
BAZ2B
BEX2
BRD1
BRMS1
BRMS1L
BRPF1
BYSL
C1orf35
C7orf25
C8orf33
CARD9
CAVIN3
CBX8
CCDC187
CCDC85B
CDC37
CDC73
CDCA7L
CEP57L1
CFAP53
CLPB
COIL
CWF19L2
DAXX
DAZAP2
DDX41
DDX6
DNAJB11
DNTTIP2
DVL3
EAF1
EBNA1BP2
EIF3D
ELOA
ELOA2
EMD
EMP1
ENKD1
ERCC3
FAM118B
FAM124A
FAM133A
FAM13C
FAM161A
FAM161B
FAM214B
FAM90A1
GADD45GIP1
GAS8
GATAD2B
GCC1
GEM
GLYCTK
GPATCH2L
GPATCH4
GPX7
GSE1
HAUS1
HDAC4
HDAC6
HIC2
HMGB4
HOXB5
HOXC8
HSPD1
IK
INO80B
INPP5J
IPCEF1
IQCE
IQUB
ITPKB
KANK2
KANSL1
KAT14
KAT5
KAT7
KDM1A
KRI1
KRT31
LAMTOR5
LCOR
LENG1
LENG8
LIN37
LNX1
MAB21L2
MAGOH
MBD3
MCM10
MCRS1
MEST
METTL17
MFAP1
MKRN3
MRPL44
NEBL
NIPSNAP3A
NKAP
NKAPD1
NOL12
NOP2
NOP53
NOXA1
NRIP1
NTAQ1
NUSAP1
ODAD4
PAM16
PIBF1
PIMREG
PKN1
PLA2G2A
PPFIA1
PPIG
PPP1R16B
PPP1R18
PRKRIP1
PRPF18
PRPF3
PRPF31
PSMA1
PSORS1C2
RASSF10
RBM10
RCOR3
RHPN1
RNF169
RNF6
RPL13
SCNM1
SEC14L1
SERPINH1
SETD5
SFR1
SH2D4A
SLU7
SMARCE1
SNRPD2
SNW1
SOD2
SPANXN3
SRGN
SSX3
STK25
STMN2
SUV39H1
SUV39H2
SYT17
SYTL4
SYTL5
TAF1D
TBC1D22B
TBC1D30
TCAF1
TCEANC
TEAD4
TLK2
TRAF3IP3
TRIM29
TRIM3
TRIM42
TSFM
TSGA10IP
TSHZ3
TTLL10
TXLNB
TXN2
USP2
UTP11
UTP14A
UTP14C
UTP25
UTP3
VXN
WT1
YJU2
ZBTB16
ZBTB24
ZBTB4
ZBTB47
ZBTB48
ZBTB49
ZBTB8A
ZCCHC10
ZFC3H1
ZFHX3
ZFP1
ZFP91
ZGPAT
ZNF136
ZNF140
ZNF148
ZNF165
ZNF169
ZNF17
ZNF20
ZNF202
ZNF227
ZNF239
ZNF264
ZNF266
ZNF302
ZNF329
ZNF35
ZNF366
ZNF408
ZNF410
ZNF417
ZNF426
ZNF433
ZNF439
ZNF490
ZNF491
ZNF555
ZNF557
ZNF572
ZNF574
ZNF578
ZNF587
ZNF599
ZNF607
ZNF648
ZNF669
ZNF688
ZNF696
ZNF775
ZNF777
ZNF785
ZNF835
ZNF860
ZSCAN12
ZSCAN21
ZSCAN23
179 interacting genes:
A2M
ACTB
ACTG1
AKT1
AMOTL2
APOE
APP
AR
BEND7
BHLHB9
BLZF1
BTBD10
BTBD3
C19orf44
CAMK2A
CAMK2B
CAMK2G
CARD10
CARD9
CAVIN1
CBY2
CC2D1A
CCDC138
CCDC152
CCDC91
CCHCR1
CDC37L1
CDK2
CDK3
CDK4
CDK5
CDK6
CDK7
CEP55
CEP70
CGGBP1
CHGA
CHUK
CKS1B
CKS2
CRYM
CSNK2A1
CSNK2A2
CT45A1
CTAG1A
CTAG1B
CUTC
CYP2C9
DCTN1
DEAF1
DISC1
ECSIT
EIF2AK1
EIF2S1
ELAVL3
ENOX2
EXOSC1
FAM118A
FAM9B
FATE1
FBXL12
FBXW4
GAS7
GAS8
GCDH
GCH1
GFAP
GMCL1
GOLGA2
GOLGA6L9
GRAMD2B
GRIPAP1
HIVEP1
HOMER3
HSF2BP
HSP90AA1
IFIT5
IKBKB
IKBKE
IKBKG
IKZF3
IMMT
JRK
KATNBL1
KCTD13
KCTD9
KIFC3
KLHL2
KRT75
KRT76
LMNB2
LONP1
LOXL4
LUC7L2
LZTS1
MAD1L1
MAP3K14
MAP3K3
MDFI
MID1
MIPOL1
MRPL9
MTOR
MZT2B
NCOA5
NECAB1
NECAB2
NOS3
NR2C2
NRIP3
NT5C1A
OGA
OGT
PAICS
PDE9A
PIBF1
PNMA2
POU6F2
PPHLN1
PPP5C
PRAM1
PRDX2
PRKAR1B
PRMT1
PRMT5
PRPH
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMC6
PSME1
PTGES3
RABGEF1
RAD23A
RAF1
REEP6
RNF32
ROPN1
RPS15A
SAFB
SEPTIN3
SNX5
SPTBN4
SQSTM1
SRC
SRRM4
SSNA1
STAMBPL1
STIP1
STK11
STK32A
STX1A
SYCE2
SYCP3
TBK1
TCF4
THAP1
THAP7
TNFAIP1
TNIP1
TRAF2
TRAF3
TRAF5
TRIM54
UBE2I
USHBP1
WAC
ZBED1
ZBTB26
ZBTB8A
ZNF205
ZNF235
ZNF266
ZNF276
ZNF655
ZNF667
ZNF837
Entrez ID
80321
11140
HPRD ID
16779
05456
Ensembl ID
ENSG00000114107
ENSG00000105401
Uniprot IDs
A0A140VJG2
B7Z2D2
Q8NHQ1
A0A024R7B7
Q16543
PDB IDs
1US7
2K5B
2N5X
2NCA
2W0G
5FWK
5FWL
5FWM
5FWP
5HPE
Enriched GO Terms of Interacting Partners
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