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CDC37 and CDK7
Number of citations of the paper that reports this interaction (PubMedID
26186194
)
524
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, proximity labelling technology, pull down)
CDC37
CDK7
Description
cell division cycle 37, HSP90 cochaperone
cyclin dependent kinase 7
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Extracellular Exosome
Chaperone Complex
HSP90-CDC37 Chaperone Complex
Transcription Factor TFIIH Core Complex
Fibrillar Center
Nucleus
Nucleoplasm
Transcription Factor TFIIH Holo Complex
Cytoplasm
Cytosol
Plasma Membrane
Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex
Perinuclear Region Of Cytoplasm
CAK-ERCC2 Complex
Transcription Factor TFIIK Complex
Molecular Function
Protein Binding
Protein Kinase Regulator Activity
Kinase Binding
Protein Kinase Binding
Heat Shock Protein Binding
Unfolded Protein Binding
Chaperone Binding
Hsp90 Protein Binding
Scaffold Protein Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
ATP-dependent Activity, Acting On DNA
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Protein Serine Kinase Activity
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Folding
Protein Targeting
Posttranscriptional Regulation Of Gene Expression
Protein Stabilization
Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
DNA Repair
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Cell Cycle
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Cell Division
Regulation Of Cell Cycle
Phosphorylation Of RNA Polymerase II C-terminal Domain
Pathways
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Constitutive Signaling by EGFRvIII
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
RHOBTB2 GTPase cycle
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Phosphonothreonine
Alvocidib
SNS-032
Seliciclib
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
LDL cholesterol levels in HIV infection (
33109212
)
Multiple sclerosis (
21833088
)
White blood cell count (
32888494
)
Interacting Genes
179 interacting genes:
A2M
ACTB
ACTG1
AKT1
AMOTL2
APOE
APP
AR
BEND7
BHLHB9
BLZF1
BTBD10
BTBD3
C19orf44
CAMK2A
CAMK2B
CAMK2G
CARD10
CARD9
CAVIN1
CBY2
CC2D1A
CCDC138
CCDC152
CCDC91
CCHCR1
CDC37L1
CDK2
CDK3
CDK4
CDK5
CDK6
CDK7
CEP55
CEP70
CGGBP1
CHGA
CHUK
CKS1B
CKS2
CRYM
CSNK2A1
CSNK2A2
CT45A1
CTAG1A
CTAG1B
CUTC
CYP2C9
DCTN1
DEAF1
DISC1
ECSIT
EIF2AK1
EIF2S1
ELAVL3
ENOX2
EXOSC1
FAM118A
FAM9B
FATE1
FBXL12
FBXW4
GAS7
GAS8
GCDH
GCH1
GFAP
GMCL1
GOLGA2
GOLGA6L9
GRAMD2B
GRIPAP1
HIVEP1
HOMER3
HSF2BP
HSP90AA1
IFIT5
IKBKB
IKBKE
IKBKG
IKZF3
IMMT
JRK
KATNBL1
KCTD13
KCTD9
KIFC3
KLHL2
KRT75
KRT76
LMNB2
LONP1
LOXL4
LUC7L2
LZTS1
MAD1L1
MAP3K14
MAP3K3
MDFI
MID1
MIPOL1
MRPL9
MTOR
MZT2B
NCOA5
NECAB1
NECAB2
NOS3
NR2C2
NRIP3
NT5C1A
OGA
OGT
PAICS
PDE9A
PIBF1
PNMA2
POU6F2
PPHLN1
PPP5C
PRAM1
PRDX2
PRKAR1B
PRMT1
PRMT5
PRPH
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMC6
PSME1
PTGES3
RABGEF1
RAD23A
RAF1
REEP6
RNF32
ROPN1
RPS15A
SAFB
SEPTIN3
SNX5
SPTBN4
SQSTM1
SRC
SRRM4
SSNA1
STAMBPL1
STIP1
STK11
STK32A
STX1A
SYCE2
SYCP3
TBK1
TCF4
THAP1
THAP7
TNFAIP1
TNIP1
TRAF2
TRAF3
TRAF5
TRIM54
UBE2I
USHBP1
WAC
ZBED1
ZBTB26
ZBTB8A
ZNF205
ZNF235
ZNF266
ZNF276
ZNF655
ZNF667
ZNF837
45 interacting genes:
ADAMTS6
APP
AR
BRCA1
CCND2
CCNH
CDC37
CDK1
CDK2
CDK6
CDK9
CTDP1
CUX1
E2F1
ERCC2
ERCC3
ESR1
GTF2E1
GTF2E2
GTF2H1
GTF2H2
GTF2H3
GTF2H5
H1-1
HLA-DQA1
HSD17B4
LASP1
MBP
MCM7
MNAT1
NEK6
PCGF6
POLR2B
PRKCI
RARA
SMAD1
SRPK1
SRPK2
SUPT5H
TAF7
TCEA1
THRA
TP53
UBE2D1
VDR
Entrez ID
11140
1022
HPRD ID
05456
15993
Ensembl ID
ENSG00000105401
ENSG00000134058
Uniprot IDs
A0A024R7B7
Q16543
A0A0S2Z3F9
D6R9G1
D6RFL0
P50613
PDB IDs
1US7
2K5B
2N5X
2NCA
2W0G
5FWK
5FWL
5FWM
5FWP
5HPE
1LG3
1PA8
1UA2
2HIC
6O9L
6XBZ
6XD3
7B5O
7B5Q
Enriched GO Terms of Interacting Partners
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