THOC7 and GOT2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		THOC7	GOT2
Description		THO complex 7	glutamic-oxaloacetic transaminase 2
Image
GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Cell Surface T-tubule Protein-containing Complex Perikaryon Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding	RNA Binding L-aspartate:2-oxoglutarate Aminotransferase Activity Phospholipid Binding Kynurenine-oxoglutarate Transaminase Activity Amino Acid Binding Enzyme Binding Pyridoxal Phosphate Binding Carboxylic Acid Binding Identical Protein Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus RNA Splicing Viral MRNA Export From Host Cell Nucleus	2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Female Pregnancy Lactation Response To Muscle Activity Fatty Acid Transport 4-hydroxyproline Catabolic Process Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Response To Insulin Response To Morphine Response To Ethanol L-kynurenine Metabolic Process
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	Degradation of cysteine and homocysteine Glyoxylate metabolism and glycine degradation Gluconeogenesis Aspartate and asparagine metabolism Glutamate and glutamine metabolism
Drugs			Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Neutrophil count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)	Aortic root size ( 21223598) Aspartate aminotransferase levels ( 33547301 29403010 33339817) Automobile speeding propensity ( 30643258) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) High density lipoprotein cholesterol levels ( 33339817) Impulsivity (attentional) ( 30718321) Metabolite levels ( 23823483) QT interval ( 19305408) Serum metabolite levels ( 33031748) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 31959995) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		11 interacting genes: CCDC146 CHD3 CKAP4 GOT2 MED22 MED8 MNS1 NDC80 NIF3L1 SMARCD1 THOC5	12 interacting genes: APCS BBS2 CCL21 CSNK2A2 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6
Entrez ID		80145	2806
HPRD ID		17632	00684
Ensembl ID		ENSG00000163634	ENSG00000125166
Uniprot IDs		A0A024R332 A0A5S6STF9 Q6I9Y2	P00505
PDB IDs		7APK	5AX8
Enriched GO Terms of Interacting Partners?
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