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NR4A3 and CDKN2D
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
NR4A3
CDKN2D
Description
nuclear receptor subfamily 4 group A member 3
cyclin dependent kinase inhibitor 2D
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cyclin D2-CDK4 Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Glucocorticoid Receptor Binding
CAMP Response Element Binding
Protein Homodimerization Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Gastrulation
Pyruvate Oxidation
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Glucose Transmembrane Transport
Intracellular Receptor Signaling Pathway
Animal Organ Regeneration
Positive Regulation Of Mast Cell Cytokine Production
Common Myeloid Progenitor Cell Proliferation
Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway
Mast Cell Degranulation
Steroid Hormone Mediated Signaling Pathway
Cellular Response To Leptin Stimulus
Cellular Respiration
Fat Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fatty Acid Oxidation
Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Corticotropin-releasing Hormone Stimulus
Cellular Response To Catecholamine Stimulus
Energy Homeostasis
Positive Regulation Of Monocyte Aggregation
Negative Regulation Of Hydrogen Peroxide-induced Neuron Death
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Positive Regulation Of Feeding Behavior
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Response To UV
Negative Regulation Of Cell Growth
Response To Retinoic Acid
Response To Vitamin D
Negative Regulation Of Phosphorylation
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Autophagic Cell Death
Regulation Of Cell Cycle
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Cell Cycle G1/S Phase Transition
Pathways
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1
Drugs
Dasatinib
Diseases
GWAS
Dental caries (
23064961
)
Depression in smokers (
30219690
)
Eosinophil percentage of white cells (
32888494
)
Lung cancer (
28604730
)
Systemic lupus erythematosus (
33536424
)
Type 1 diabetes (
34127860
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Red cell distribution width (
32888494
)
Interacting Genes
43 interacting genes:
ADAMTSL4
ALPP
CDKN2D
CHRD
COPS5
CYP21A2
CYSRT1
EFEMP1
HSD3B7
KPRP
KRTAP10-1
KRTAP10-5
KRTAP10-8
KRTAP12-3
KRTAP12-4
KRTAP4-11
KRTAP4-2
KRTAP4-4
KRTAP5-11
KRTAP5-3
KRTAP5-6
KRTAP5-9
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
LCE2B
LCE2D
MACO1
NECTIN2
PCSK5
PIN1
RECK
RPS6KA1
SIX3
SMOC1
TRIM28
TSPAN4
UBE3A
VASN
VHL
VWC2L
ZNF330
63 interacting genes:
APP
BRCA1
BTG1
C1orf94
C5orf49
CCND3
CDK4
CDK6
CGGBP1
CTBP1
DDIT4L
DMRTB1
DYNLT2B
EIF4G1
FAM228A
FAM86C1P
FHL3
GATAD2B
GLYR1
GORASP2
GSC2
HSD17B14
IKZF3
INCA1
KRT75
LNX1
LONRF1
LSM3
MEI4
MEOX2
MSS51
MTF2
NDUFB7
NIF3L1
NME4
NMI
NR4A1
NR4A2
NR4A3
PICK1
PRDX5
PRIMPOL
PSMA1
QKI
REL
RUFY4
SAXO1
SDCBP
SH3GLB1
SH3GLB2
TBC1D17
TEX11
THAP1
TSG101
TSGA10IP
UQCC2
VGLL1
YPEL3
ZBTB32
ZNF396
ZNF620
ZNF688
ZNF774
Entrez ID
8013
1032
HPRD ID
02766
02957
Ensembl ID
ENSG00000119508
ENSG00000129355
Uniprot IDs
A0A024R168
Q92570
A0A024R796
P55273
PDB IDs
1BD8
1BI8
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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