POF1B and PPL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		POF1B	PPL
Description		POF1B actin binding protein	periplakin
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GO Annotations	Cellular Component	Actin Filament Adherens Junction Bicellular Tight Junction Desmosome	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome
	Molecular Function	Actin Filament Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Epithelial Cell Morphogenesis Actin Filament Organization Actin Cytoskeleton Organization Bicellular Tight Junction Assembly	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways			Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS			Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		14 interacting genes: ARL4A BCL6 COL8A1 FAM90A1 FRS3 GEM IGFN1 KCTD9 KLHL38 LGALS14 PPL RFPL3 SYT17 UCHL5	45 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 LARP1 MRPL28 OPRM1 PBX4 PICK1 PKD1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16
Entrez ID		79983	5493
HPRD ID		06679	04187
Ensembl ID		ENSG00000124429	ENSG00000118898
Uniprot IDs		Q8WVV4	O60437
PDB IDs		3BH9	4Q28
Enriched GO Terms of Interacting Partners?
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