PPL and MRPL28

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PPL	MRPL28
Description		periplakin	mitochondrial ribosomal protein L28
Image
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Mitochondrial Large Ribosomal Subunit Cytosol
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization	Translation
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases
GWAS		Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)	Body mass index ( 26426971) Heel bone mineral density ( 28869591) Refractive error ( 32231278)
Interacting Genes		45 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 LARP1 MRPL28 OPRM1 PBX4 PICK1 PKD1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	29 interacting genes: ABI2 APP BANP BBS4 CDCA7L CDR2 ENKD1 FAM9B HMBOX1 HSPB1 HTR2A IKZF3 LARP1B LENG1 LRRK2 NFKBID OXA1L PPL SCNM1 TEF TRAF3IP2 TRAF4 TSHZ3 TSSK3 TUBB3 UPP2 USP2 USP20 ZNF655
Entrez ID		5493	10573
HPRD ID		04187	06889
Ensembl ID		ENSG00000118898	ENSG00000086504
Uniprot IDs		O60437	Q13084
PDB IDs		4Q28	3J7Y 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5H 7A5I 7A5J 7A5K
Enriched GO Terms of Interacting Partners?
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