CPSF7 and CLK2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		CPSF7	CLK2
Description		cleavage and polyadenylation specific factor 7	CDC like kinase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane	Nucleus Nucleoplasm Nuclear Body Nuclear Speck
	Molecular Function	RNA Binding Protein Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Tetramerization Protein Heterotetramerization Pre-mRNA Cleavage Required For Polyadenylation MRNA Alternative Polyadenylation Messenger Ribonucleoprotein Complex Assembly	Protein Phosphorylation Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation
Pathways		mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs RHOBTB1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		62 interacting genes: APBB1 ARMC7 ATXN1 CATSPER1 CCDC86 CFAP206 CLK2 CSNK2A1 DVL2 EPM2AIP1 EWSR1 GAS8 GCC1 GRB2 GUCD1 HINT1 HNRNPF ITCH LENG8 LNX1 MAILR MIR1-1 MIR1-2 MIR10B MIR128-2 MIR141 MIR155 MIR16-1 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR25 MIR29C MIR34B MIR7-1 MIR9-2 MIR93 MIRLET7B NCK2 NUDT21 OGT PATZ1 PID1 PRKAA2 PRMT2 RBM10 RUNX1T1 SEC23B SMAD3 SNRNP25 SNX18 SORBS3 SPG21 SRPK2 SUMO2 TLE5 TNS2 U2AF2 WBP4 WWOX	53 interacting genes: AKT1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUZP4 MRPL4 NXF1 PRM1 PRPF38A PTPN1 RBM39 RNF8 RNPS1 RSRP1 SDCBP SNIP1 SNRNP70 SRPK2 SRRM1 SRSF3 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21
Entrez ID		79869	1196
HPRD ID		16906	04289
Ensembl ID		ENSG00000149532	ENSG00000176444
Uniprot IDs		B4DGF8 Q8N684	A8K7I0 B7Z8N6 P49760
PDB IDs		3N9U	3NR9 5UNP 6FYI 6FYK 6FYL 6KHE
Enriched GO Terms of Interacting Partners?
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