ANKRD55 and SNX18

		ANKRD55	SNX18
Description		ankyrin repeat domain 55	sorting nexin 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Endosome Membrane Clathrin-coated Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process		Mitotic Cytokinesis Endocytosis Protein Transport Endosomal Transport Cleavage Furrow Formation Positive Regulation Of GTPase Activity
Pathways			Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alzheimer's disease (cognitive decline) ( 23535033) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fasting insulin ( 33402679) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA levels ( 28628107) IgG glycosylation ( 23382691) Immature fraction of reticulocytes ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lung function (FEV1) ( 30061609) Macular thickness ( 30535121) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 24076602 27386562) Optic disc size ( 31809533) Pediatric autoimmune diseases ( 26301688) Post-traumatic stress disorder ( 27167565) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-negative) ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sero-negative rheumatoid arthritis ( 28706201) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 20686565) Type 1 diabetes ( 34127860) Type 2 diabetes ( 27189021 22885922 26961502 29358691 30297969 26818947 32499647 30718926 28869590) Urate levels ( 23263486) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Immune response to smallpox vaccine (IL-6) ( 22542470)
Interacting Genes		24 interacting genes: ABI2 ANKS1A BACH2 BANP BOLA2 BOLA2B CABP5 CFAP206 CLIC3 FHL2 FHL5 FRS3 HGS HSF2BP NCK2 NOXA1 PFDN5 PTK6 SETD9 SNX18 TEKT4 TRIM23 ZMYND19 ZSCAN1	20 interacting genes: ABI2 ANKRD55 CPSF7 CYSRT1 DPPA4 GABARAP GOLGA2 HSF2BP HSPB2 HSPB2-C11orf52 KHDRBS3 KRTAP1-1 KRTAP6-3 MAP1LC3B MDFI MSS51 PTPN21 SOS1 SOS2 ZBTB42
Entrez ID		79722	112574
HPRD ID		07758	15407
Ensembl ID		ENSG00000164512	ENSG00000178996
Uniprot IDs		Q3KP44	Q96RF0
PDB IDs
Enriched GO Terms of Interacting Partners?
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