C3orf52 and ZNRF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		C3orf52	ZNRF3
Description		chromosome 3 open reading frame 52	zinc and ring finger 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Wnt Receptor Catabolic Process Limb Development Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways			Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)	Body shape index ( 34021172) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Diastolic blood pressure ( 27618448 30487518) Gut microbiota (bacterial taxa) ( 27694959) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 29403010 27618448 30487518) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 29422604 25086665) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 27618448 30578418) Type 2 diabetes ( 32499647) Waist circumference adjusted for body mass index ( 34021172 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White blood cell count ( 32888494)
Interacting Genes		72 interacting genes: ADGRG3 AGER AHNAK2 AMIGO1 AQP6 ATP1B4 BIK CCL21 CCL26 CD33 CHST13 CLDN7 CLEC10A CNMD CPLX4 CREB3 DEXI ERGIC3 ERP29 ESAM FAM209A FFAR2 FNDC9 FOLH1 FUT3 GJA8 GJB1 GOLM2 GORAB HHLA2 HSD17B13 KEL KIR2DL3 KLRC1 LEUTX LHFPL5 LMNA LRRC25 MFF MGST2 MGST3 MRGPRX3 MUC1 NCR3LG1 NEMP1 NPDC1 NSG2 PVR QPCTL REEP3 RNF150 SAR1A SGTA SIGLECL1 SLC10A2 SLC16A2 SLC23A2 SLC39A2 SPRING1 ST6GALNAC3 STOM SYNE4 TIMMDC1 TMEM179B TMEM237 TMEM45B TMEM52B TMEM80 TMPRSS2 TMX2 UPK2 ZNRF3	8 interacting genes: C3orf52 GFI1B HOXA1 HSPB1 RSPO1 RSPO2 RSPO3 UBE2N
Entrez ID		79669	84133
HPRD ID		08018	11737
Ensembl ID		ENSG00000114529	ENSG00000183579
Uniprot IDs		Q5BVD1	A0A024R1J1 Q9ULT6
PDB IDs
Enriched GO Terms of Interacting Partners?
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