PPP1R3B and PPP1CB

Number of citations of the paper that reports this interaction (PubMedID 23414517)
13

Data Source:
BioGRID (two hybrid)

		PPP1R3B	PPP1CB
Description		protein phosphatase 1 regulatory subunit 3B	protein phosphatase 1 catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Glycogen Granule Intracellular Membrane-bounded Organelle	Protein Phosphatase Type 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Glycogen Granule Extracellular Exosome PTW/PP1 Phosphatase Complex
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity [phosphorylase] Phosphatase Activity Glycogen Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Regulation Of Catalytic Activity	MAPK Cascade Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Cell Cycle Regulation Of Cell Adhesion Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Cell Division
Pathways			Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition Circadian Clock RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Alcohol use disorder (consumption score) ( 30940813) Aluminium levels ( 26025379) Alzheimer's disease ( 22832961) Apolipoprotein A1 levels ( 33730874) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine consumption from coffee or tea ( 33287642) Cholesterol, total ( 24097068 25961943 20686565) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 25631608 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting glucose ( 33402679) Fasting insulin ( 33402679) FEV1 ( 30804560) Fibrinogen levels ( 28107422) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pregnancy) ( 23903356) Glycine levels ( 31070104) HDL cholesterol ( 23726366 24097068 23505323 21347282 25961943 20686565) HDL cholesterol levels ( 28334899) Iron status biomarkers (total iron binding capacity) ( 28334935) Joint mobility (Beighton score) ( 27182965) LDL cholesterol ( 24097068 20864672 25961943 20686565) LDL cholesterol levels ( 28334899) Liver enzyme levels (alkaline phosphatase) ( 22001757) Liver volume ( 34128465) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Myopia (pathological) ( 23049088) Neuroticism ( 29255261) Nose size ( 27182965) Number of sexual partners ( 30643258) Peak expiratory flow ( 30804560) Plasma lactate levels ( 26433129) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total cholesterol levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Body mass index ( 25673413) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Excessive sweating ( 29895819) Heel bone mineral density ( 30598549 28869591) Pre-treatment viral load in HIV-1 infection ( 31219150) Pure non-grapefruit juice consumption ( 31046077)
Interacting Genes		7 interacting genes: IFNAR2 PLCE1 PPP1CA PPP1CB PPP1CC PYGB PYGM	51 interacting genes: AATK ACTN2 AURKA BRCA1 C14orf180 CHCHD3 CLK1 CLOCK CSNK2B CSRNP1 CSRNP2 CYSRT1 DELEC1 FBXO7 H3-3A H3C1 HOXA2 KANK2 KIF23 LMTK2 MAPT MEOX2 NCOA1 NONO PHACTR3 PPP1R11 PPP1R12B PPP1R12C PPP1R16A PPP1R16B PPP1R27 PPP1R2B PPP1R2C PPP1R3A PPP1R3B PPP1R3C PPP1R7 PPP1R9A PPP1R9B PPP2R5C PRKAR2A PTK2 RB1 RORC SH2D4A SPATC1L TLX1 TP53BP2 UBAC1 WBP11 ZFYVE9
Entrez ID		79660	5500
HPRD ID		17894	11792
Ensembl ID		ENSG00000173281	ENSG00000213639
Uniprot IDs		Q86XI6	P62140 V9HW04
PDB IDs		2EEF 5ZT0
Enriched GO Terms of Interacting Partners?
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