PPP1CB and WBP11

Number of citations of the paper that reports this interaction (PubMedID 14640981)
19

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PPP1CB	WBP11
Description		protein phosphatase 1 catalytic subunit beta	WW domain binding protein 11
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Glycogen Granule Extracellular Exosome PTW/PP1 Phosphatase Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Single-stranded DNA Binding RNA Binding Protein Binding WW Domain Binding
	Biological Process	MAPK Cascade Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Cell Cycle Regulation Of Cell Adhesion Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Cell Division	RRNA Processing MRNA Cis Splicing, Via Spliceosome
Pathways		Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition Circadian Clock RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body mass index ( 25673413) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Excessive sweating ( 29895819) Heel bone mineral density ( 30598549 28869591) Pre-treatment viral load in HIV-1 infection ( 31219150) Pure non-grapefruit juice consumption ( 31046077)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		51 interacting genes: AATK ACTN2 AURKA BRCA1 C14orf180 CHCHD3 CLK1 CLOCK CSNK2B CSRNP1 CSRNP2 CYSRT1 DELEC1 FBXO7 H3-3A H3C1 HOXA2 KANK2 KIF23 LMTK2 MAPT MEOX2 NCOA1 NONO PHACTR3 PPP1R11 PPP1R12B PPP1R12C PPP1R16A PPP1R16B PPP1R27 PPP1R2B PPP1R2C PPP1R3A PPP1R3B PPP1R3C PPP1R7 PPP1R9A PPP1R9B PPP2R5C PRKAR2A PTK2 RB1 RORC SH2D4A SPATC1L TLX1 TP53BP2 UBAC1 WBP11 ZFYVE9	33 interacting genes: APBB1 ARF1 C5orf22 CD2BP2 CTNNBL1 CYGB DDX17 DDX5 FYN GIGYF2 GRB2 ITSN1 MCRS1 MORN4 NCK2 NOD2 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRPF40A RBM5 RTN4IP1 RUNX1T1 SEC23A SRC TESC TRAF4 TRIP10 UBASH3A VIM WBP4
Entrez ID		5500	51729
HPRD ID		11792	18293
Ensembl ID		ENSG00000213639	ENSG00000084463
Uniprot IDs		P62140 V9HW04	A0A024RAW9 Q9Y2W2
PDB IDs			7ABF 7ABG
Enriched GO Terms of Interacting Partners?
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