HECTD3 and PPL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HECTD3	PPL
Description		HECT domain E3 ubiquitin protein ligase 3	periplakin
Image		No pdb structure
GO Annotations	Cellular Component	Perinuclear Region Of Cytoplasm	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Syntaxin Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS			Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		8 interacting genes: BRCA1 CASP8 CASP9 PPL TP53 TRIOBP UBE2D2 ZDHHC17	45 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 LARP1 MRPL28 OPRM1 PBX4 PICK1 PKD1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16
Entrez ID		79654	5493
HPRD ID		13383	04187
Ensembl ID		ENSG00000126107	ENSG00000118898
Uniprot IDs		A1A4G1 B3KU34 Q5T447	O60437
PDB IDs			4Q28
Enriched GO Terms of Interacting Partners?
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