BRME1 and GPS2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BRME1	GPS2
Description		break repair meiotic recombinase recruitment factor 1	G protein pathway suppressor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Chromosome	Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrion Cytosol Transcription Repressor Complex
	Molecular Function	Molecular_function Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding
	Biological Process	Female Meiosis I Multicellular Organism Development Spermatogenesis Double-strand Break Repair Involved In Meiotic Recombination	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways			PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases
GWAS			Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		34 interacting genes: ADAMTSL4 AIMP2 AKAP8L APP C19orf25 CENPQ COPS4 CTNNAL1 CYSRT1 EWSR1 FAM9B FBXO25 GDF15 GPS2 HAUS3 HOMER1 IKBKG KRT31 KRT34 KRT38 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 NBPF19 NOTCH2NLA PSMA6 RABL6 RUNX1T1 STXBP1 TRIM23 TSC22D3 VCL	55 interacting genes: AKAP8L ATF4 ATF5 BAG4 BRME1 C19orf54 CCNA1 CHD3 CNOT2 CYSRT1 DAZAP2 ELOB EP300 FAM168B FHL5 GOLGA2 HDAC1 HDAC3 HNRNPH1 HOXA1 INTS11 KRT27 KRT31 KRT34 KRT36 KRTAP11-1 KRTAP13-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 MAP3K7CL MYH10 NCOR1 NDOR1 NR0B2 OIP5 PBK POU2AF1 PRMT6 PRR22 RBPMS SESTD1 SETDB1 SMUG1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53 TP53BP2 TRIP6 UBTD2 VPS37C
Entrez ID		79173	2874
HPRD ID		14415	11878
Ensembl ID		ENSG00000132016	ENSG00000132522
Uniprot IDs		Q0VDD7	Q13227
PDB IDs			2L5G
Enriched GO Terms of Interacting Partners?
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