GPS2 and CNOT2

Number of citations of the paper that reports this interaction (PubMedID 16712523)
14

Data Source:
BioGRID (two hybrid)

		GPS2	CNOT2
Description		G protein pathway suppressor 2	CCR4-NOT transcription complex subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrion Cytosol Transcription Repressor Complex	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding	Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Population Maintenance
Pathways		PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)	Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369) Triglyceride levels ( 32154731)
Interacting Genes		55 interacting genes: AKAP8L ATF4 ATF5 BAG4 BRME1 C19orf54 CCNA1 CHD3 CNOT2 CYSRT1 DAZAP2 ELOB EP300 FAM168B FHL5 GOLGA2 HDAC1 HDAC3 HNRNPH1 HOXA1 INTS11 KRT27 KRT31 KRT34 KRT36 KRTAP11-1 KRTAP13-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 MAP3K7CL MYH10 NCOR1 NDOR1 NR0B2 OIP5 PBK POU2AF1 PRMT6 PRR22 RBPMS SESTD1 SETDB1 SMUG1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53 TP53BP2 TRIP6 UBTD2 VPS37C	26 interacting genes: ARMC5 BCL6 BEX1 C11orf1 C20orf85 CCHCR1 CNOT1 CNOT3 CNOT4 CNOT8 CSTF2 DDB1 GALNT10 GCSAM GPS1 GPS2 HSF2BP MTFR1L NCOR1 NCOR2 PRR35 PSMB4 RACK1 TBX2 TEKT3 ZFHX3
Entrez ID		2874	4848
HPRD ID		11878	05367
Ensembl ID		ENSG00000132522	ENSG00000111596
Uniprot IDs		Q13227	A0A024RBD8 B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8
PDB IDs		2L5G	4C0D 4C0F 5FU6 5FU7
Enriched GO Terms of Interacting Partners?
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