C11orf49 and ARHGEF15

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
HPRD (two hybrid)

		C11orf49	ARHGEF15
Description		chromosome 11 open reading frame 49	Rho guanine nucleotide exchange factor 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol Dendrite
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process		Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Activation Of GTPase Activity Negative Regulation Of Synapse Maturation
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) D-dimer levels ( 21502573) HDL cholesterol levels ( 32203549) Hip index ( 34021172) Intraocular pressure ( 29617998) Neurociticism ( 29500382)	Bipolar disorder ( 28115744) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) Platelet distribution width ( 32888494) Total cholesterol levels ( 30275531) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: ARHGEF15 CDC16 ENY2 FH GCA GSR PHF1 PNMA5 PRKAR1A PSMA1 RAB17 RAB29 RBM48 RPL8 RPS3A TXN2 UBE3A UBQLN4 ZFHX3	14 interacting genes: C11orf49 CDC42 CEP55 DNAJC5 EPHA4 ESR1 ESRRG GORASP2 LASP1 MOB4 PIN1 PRKG1 RHOA SH3RF1
Entrez ID		79096	22899
HPRD ID		08332	10535
Ensembl ID		ENSG00000149179	ENSG00000198844
Uniprot IDs		B4DUV7 Q9H6J7	A0A0S2Z547 O94989
PDB IDs
Enriched GO Terms of Interacting Partners?
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