LRP8 and KCNJ15

		LRP8	KCNJ15
Description		LDL receptor related protein 8	potassium inwardly rectifying channel subfamily J member 15
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Microtubule Associated Complex Plasma Membrane Caveola Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity Protein N-terminus Binding Calcium-dependent Protein Binding	Inward Rectifier Potassium Channel Activity Protein Binding
	Biological Process	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Chemical Synaptic Transmission Response To Xenobiotic Stimulus Cytokine-mediated Signaling Pathway Ventral Spinal Cord Development Ammon Gyrus Development Layer Formation In Cerebral Cortex Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Innate Immune Response Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Platelet sensitization by LDL Retinoid metabolism and transport	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Yohimbine Butamben
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index (alcohol intake interaction) ( 23192594) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 28247064) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes nephropathy ( 30566433) Urinary metabolite levels in chronic kidney disease ( 31959995)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Body shape index ( 34021172) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Monocyte count ( 32888494) Non-response to antidepressants and depression ( 27622933) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		22 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 KCNJ15 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP	16 interacting genes: CBR3 CTSE DSCAM IL16 KCNE1 KCNJ16 KCNJ2 KCNJ5 LRP8 MTCH1 PATJ SLC39A2 SNTA1 SON TOR1B TTC3
Entrez ID		7804	3772
HPRD ID		04002	03659
Ensembl ID		ENSG00000157193	ENSG00000157551
Uniprot IDs		A0A590UJ98 Q14114	Q99712
PDB IDs		3A7Q 5B4X 5B4Y
Enriched GO Terms of Interacting Partners?
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