LRP8 and DAB2

Number of citations of the paper that reports this interaction (PubMedID 16101684)
30

Data Source:
BioGRID (pull down, pull down)

		LRP8	DAB2
Description		LDL receptor related protein 8	DAB adaptor protein 2
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GO Annotations	Cellular Component	Extracellular Space Microtubule Associated Complex Plasma Membrane Caveola Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex	Fibrillar Center Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Focal Adhesion Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity Protein N-terminus Binding Calcium-dependent Protein Binding	Protein Binding Protein C-terminus Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding
	Biological Process	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Chemical Synaptic Transmission Response To Xenobiotic Stimulus Cytokine-mediated Signaling Pathway Ventral Spinal Cord Development Ammon Gyrus Development Layer Formation In Cerebral Cortex Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Innate Immune Response Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Integrin-mediated Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Transport Wnt Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Platelet sensitization by LDL Retinoid metabolism and transport	Gap junction degradation Formation of annular gap junctions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index (alcohol intake interaction) ( 23192594) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 28247064) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes nephropathy ( 30566433) Urinary metabolite levels in chronic kidney disease ( 31959995)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301 29403010) Birth weight ( 31043758) Chronic kidney disease ( 31152163 20383146) Creatinine levels ( 31015462) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) Health literacy ( 31250787) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 22158540) Premature menopause in childhood cancer survivors ( 29432556) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 19838195) Urate levels ( 23263486) Waist-hip ratio ( 28552196)
Interacting Genes		22 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 KCNJ15 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP	40 interacting genes: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 FCHO1 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 LRP8 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SGIP1 SMAD2 SMAD3 SMURF2 SRC SUMO2 TGFBR1 TGFBR2
Entrez ID		7804	1601
HPRD ID		04002	03139
Ensembl ID		ENSG00000157193	ENSG00000153071
Uniprot IDs		A0A590UJ98 Q14114	A0A024R036 B2RAW0 P98082
PDB IDs		3A7Q 5B4X 5B4Y	2LSW 6O5O 6OVF
Enriched GO Terms of Interacting Partners?
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